Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Blood-brain barrier transport: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Waste Clearance | involved_in | process | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TXB2 | mediates | compound | 0.95 |
| Tfr1 | mediates | receptor | 0.95 |
| Transferrin Receptor 1 | mediates | receptor | 0.90 |
| TFR1 | participates_in | gene | 0.45 |
| PDGFRB | participates_in | gene | 0.43 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Magnetosonic-Triggered Transferrin Receptor Clustering | 0.719 | neurodegeneration | Blood-brain barrier transport mechanisms |
| Pericyte Contractility Reset via Selective PDGFR-β Agonism | 0.684 | neurodegeneration | Perivascular spaces and glymphatic clear |
| Transferrin-Alectinib Conjugation Enhances Blood-Brain Barri | 0.406 | molecular biology | Does Alectinib truly bind C1q directly w |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.841
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.773
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| iPSC-derived endothelial cell iron uptake with RLS CSF exposure | exploratory | restless legs syndrome | 0.900 | 0.00 | iPSC-derived human endothelial | proposed | N/A |
| Irisin effects on angiogenesis in human endothelial cells | exploratory | bone fracture | 0.900 | 0.00 | human umbilical vein endotheli | proposed | N/A |
| s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin | falsification | Neuroinflammation | 0.400 | 0.50 | mouse | proposed | $200,000 |
| s:** - Compare uptake with/without magnetic particles using tight junc | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $120,000 |
| AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
| AAV Serotype Comparison for LRRK2 Knockdown in PD | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
| Proposed experiment from debate on Perivascular spaces and glymphatic | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| Vascular Contribution to Alzheimer's Disease — Beyond Amyloid | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Vascular Contributions to Alzheimer Disease and Mixed Pathology | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic [PMID:40848726] | Zhao S, Li R, Xia Y, Wang X, Liu Z, Chu | Cell Stem Cell | 2025 | 1 |
| Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease. [PMID:40425446] | Sehlin D, Hultqvist G, Michno W, Aguilar | J Prev Alzheimers Dis | 2025 | 1 |
| Neurovascular unit, neuroinflammation and neurodegeneration markers in brain dis [PMID:39526043] | Kempuraj D, Dourvetakis KD, Cohen J, Val | Front Cell Neurosci | 2024 | 1 |
| Effect of ferroptosis on chronic cerebral hypoperfusion in vascular dementia. [PMID:37709116] | Fu P, Chen Y, Wu M, Bao B, Yin X, Chen Z | Exp Neurol | 2023 | 1 |
| The Genetics of Primary Familial Brain Calcification: A Literature Review. [PMID:37446066] | Chen SY, Ho CJ, Lu YT, Lin CH, Lan MY, T | Int J Mol Sci | 2023 | 1 |
| Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044] | Calvier L, Herz J, Hansmann G | JACC Basic Transl Sci | 2022 | 1 |
| On Iron Metabolism and Its Regulation. [PMID:33925597] | Vogt AS, Arsiwala T, Mohsen M, Vogel M, | Int J Mol Sci | 2021 | 1 |
| Decoding myofibroblast origins in human kidney fibrosis. [PMID:33176333] | Kuppe C, Ibrahim MM, Kranz J, Zhang X, Z | Nature | 2021 | 1 |
| Transferrin Receptor Is a Specific Ferroptosis Marker. [PMID:32160546] | Feng H, Schorpp K, Jin J, Yozwiak CE, Ho | Cell Rep | 2020 | 1 |
| APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. [PMID:32376954] | Montagne A, Nation DA, Sagare AP, Barisa | Nature | 2020 | 1 |
| Transferrin and transferrin receptors update. [PMID:29969719] | Kawabata H | Free Radic Biol Med | 2019 | 1 |
| Pathophysiology of Primary Familial Brain Calcification. [PMID:41212990] | Keller A | Annual review of physiology | 2026 | 0 |
| A FZD4/LRP5 agonist restores pericyte coverage and vascular integrity by increas [PMID:41890033] | Levey J, Howe M, Douglas K, Odame E, Raj | bioRxiv : the preprint server | 2026 | 0 |
| Time- and dose-dependent effects of bacterial infection on iron metabolism, infl [PMID:41619877] | Lu Y, Zhang Y, Niu C | Comp Biochem Physiol A Mol Int | 2026 | 0 |
| Ayanin combats against barium sulphate nanoparticles induced hepatotoxicity via [PMID:41666660] | Zhu D, Lu Y, Jamil S, Ashfaq H, Al-Emam | J Trace Elem Med Biol | 2026 | 0 |
| Role of iron and TfR1 in the application of high‑dose ascorbate against pancreat [PMID:41789665] | Piotrowsky A, Leischner C, Schmieder H, | Oncol Rep | 2026 | 0 |
| Nano-Enabled Fluorescence Switching: A Novel Strategy for PDGFRβ Detection and T [PMID:41884335] | Fu X, Fan J, Chen H, Zheng Y, Liu Y, Zha | Research (Washington, D.C.) | 2026 | 0 |
| Loss of Pericyte Exacerbates Alzheimer's Disease-Associated Retinal Pathology. [PMID:41814129] | Hai-Chao C, Fu-Lin G, Jia-Xin C, Yi-Shu | Clinical & experimental ophtha | 2026 | 0 |
| Yangxin granules exert cardioprotective effects against acute myocardial infarct [PMID:41868900] | Huo G, Zhou Y, Wu Z, Sun S, Zhu G, Cheng | American journal of translatio | 2026 | 0 |
| Conformational dynamics study of TfR1 upon transferrin binding via NMA and MD si [PMID:41921418] | Zemmouche M, Falque G, Cadet F, Gardebie | Journal of molecular graphics | 2026 | 0 |
Multi-agent debates referencing this entity