gene

BSCL2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about BSCL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for BSCL2

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🧬 Gene Info

Gene Symbol	BSCL2
Chromosome	11q13.1.
Function	Located in the ER membrane, seipin forms oligomeric complexes that facilitate the nucleation and growth of lipid droplets 1.
Primary Expression	cortical and cerebellar neurons, with particular enrichment in Purkinje cells and hippocampal pyramidal neurons [3](https://pubmed
Ensembl ID	ENSG00000128590
GeneCards	BSCL2
Human Protein Atlas	BSCL2
Lipid droplet nucleation	Initiating the formation of lipid droplets from ER-localized lipid precursors
Lipid droplet growth	Facilitating the expansion of lipid droplets through lipid transfer
Lipid droplet positioning	Ensuring proper subcellular distribution of lipid droplets
FITM proteins	Fat storage-inducing transmembrane proteins that cooperate with seipin in lipid droplet formation
ACSL enzymes	Acyl-CoA synthetases involved in fatty acid metabolism
LD proteins	Lipid droplet-associated proteins that regulate droplet dynamics
Synaptic vesicle biogenesis	Proper lipid composition is required for vesicle formation and trafficking
Neurotransmitter release	Synaptic membrane fluidity and fusion properties depend on lipid composition
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

BSCL2

gene · 1554 words

→

BSCL2 Protein - Seipin

protein · 640 words

→

Pathway Diagram

graph TD
    BSCL2["BSCL2"]
    neurodegeneration["neurodegeneration"]
    BSCL2 -->|"implicated_in"| neurodegeneration
    style BSCL2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning BSCL2 in their description or question text

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