| Gene Symbol | BSCL2 |
| Chromosome | 11q13.1. |
| Function | Located in the ER membrane, seipin forms oligomeric complexes that facilitate the nucleation and growth of lipid droplets 1. |
| Primary Expression | cortical and cerebellar neurons, with particular enrichment in Purkinje cells and hippocampal pyramidal neurons [3](https://pubmed |
| Ensembl ID | ENSG00000128590 |
| GeneCards | BSCL2 |
| Human Protein Atlas | BSCL2 |
| Lipid droplet nucleation | Initiating the formation of lipid droplets from ER-localized lipid precursors |
| Lipid droplet growth | Facilitating the expansion of lipid droplets through lipid transfer |
| Lipid droplet positioning | Ensuring proper subcellular distribution of lipid droplets |
| FITM proteins | Fat storage-inducing transmembrane proteins that cooperate with seipin in lipid droplet formation |
| ACSL enzymes | Acyl-CoA synthetases involved in fatty acid metabolism |
| LD proteins | Lipid droplet-associated proteins that regulate droplet dynamics |
| Synaptic vesicle biogenesis | Proper lipid composition is required for vesicle formation and trafficking |
| Neurotransmitter release | Synaptic membrane fluidity and fusion properties depend on lipid composition |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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