gene

BAFFR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BAFFR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

The TNFRSF13C gene encodes BAFFR (B cell Activating Factor Receptor), essential for B cell survival, maturation, and neuroinflammation in neurodegenerative diseases.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	TNFRSF13C
Aliases	B cell Activating Factor Receptor
Chromosome	22q12.1
Protein Type	Type I transmembrane receptor
Function	Mice lacking BAFFR (Tnfrsf13c knockout) or BAFF have severely reduced mature B cell numbers - B cell maturation: BAFFR is essential for the transition of transitional B cells to mature B cells in the
Molecular Weight	~19.2 kDa
Amino Acids	184 aa
Exons	5
UniProt ID	Q9Y239
GeneCards	TNFRSF13C
Human Protein Atlas	TNFRSF13C
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: BAFFR — AlphaFold Q9Y239 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

BAFFR (B Cell Activating Factor Receptor) Protein

protein · 1194 words

→

BAFFR Gene (TNFRSF13C)

gene · 1846 words

→

Pathway Diagram

graph TD
    BAFFR["BAFFR"]
    style BAFFR fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
    neurodegeneration["neurodegeneration"]

    BAFFR -->|"implicated_in"| neurodegeneration

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
    class neurodegeneration disease

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BAFFR in their description or question text

No additional research found