Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Astrocyte-neuron lactate shuttle: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| neuronal support | regulates | process | 0.70 |
| Brain function | causes | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SLC16A1 | participates_in | gene | 0.58 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli | 0.668 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| Astrocyte-Neuron Lactate Shuttle (H6): Metabolic Coupling Re | 0.500 | neurodegeneration | Does restoring neuronal AMPK activity re |
| Novel Hypothesis on Metabolic Dysregulation in Neurodegenera | 0.330 | - | - |
| Astrocyte-Neuron Lactate Shuttle Enhancement via Pharmacolog | 0.308 | metabolomics | Metabolomic signatures of neurodegenerat |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 3 hypotheses Top: 0.541
metabolic neuroscience | 2026-04-03 | 7 hypotheses Top: 0.773
neurodegeneration | 2026-04-03 | 19 hypotheses Top: 0.869
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655] | Jorstad NL, Close J, Johansen N, Yanny A | Science | 2023 | 186 |
| Ion Channel-Extracellular Matrix Interplay in Colorectal Cancer: A Network-Based [PMID:40507957] | Terzi A, Maqoud F, Guido D, Mallardi D, | International journal of molec | 2025 | 0 |
| Direct mitochondrial import of lactate supports resilient carbohydrate oxidation [PMID:39416192] | Cluntun AA, Visker JR, Velasco-Silva JN, | bioRxiv : the preprint server | 2024 | 0 |
| Indole Derivatives as New Structural Class of Potent and Antiproliferative Inhib [PMID:36584238] | Puri S, Stefan K, Khan SL, Pahnke J, Ste | Journal of medicinal chemistry | 2023 | 0 |
| [WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268] | Wieschollek S, Forster S, Megerle K | Handchirurgie, Mikrochirurgie, | 2022 | 0 |
| SLC gene mutations and pediatric neurological disorders: diverse clinical phenot [PMID:34797406] | Mir A, Almudhry M, Alghamdi F, Albaradie | Human genetics | 2022 | 0 |
| Amyloid-β42 stimulated hippocampal lactate release is coupled to glutamate uptak [PMID:35177691] | Hascup ER, Sime LN, Peck MR, Hascup KN | Scientific reports | 2022 | 0 |
| Editor's Review and Introduction: Cognition-Inspired Artificial Intelligence. [PMID:35853452] | Cassenti DN, Veksler VD, Ritter FE | Topics in cognitive science | 2022 | 0 |
| Innovations in systemic sclerosis. [PMID:34483059] | Sindhu R Johnson | Best practice & research. | 2021 | 0 |
| Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration [PMID:34491913] | Jha MK, Passero JV, Rawat A, Ament XH, Y | The Journal of clinical invest | 2021 | 0 |
| Genome sequencing analysis identifies new loci associated with Lewy body dementi [PMID:33589841] | Chia R, Sabir MS, Bandres-Ciga S, Saez-A | Nature genetics | 2021 | 0 |
| Complete Genome Sequence of Geobacter sp. Strain FeAm09, a Moderately Acidophili [PMID:33446582] | Yadav P, Antony-Babu S, Hayes E, Healy O | Microbiology resource announce | 2021 | 0 |
| Engineering complex communities by directed evolution. [PMID:33986540] | Chang CY, Vila JCC, Bender M, Li R, Mank | Nature ecology & evolution | 2021 | 0 |
| Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100] | Tajika T, Kuboi T, Endo F, Hatori Y, Sai | Progress in rehabilitation med | 2021 | 0 |
| Neural crest-derived tumor neuroblastoma and melanoma share 1p13.2 as susceptibi [PMID:31605138] | Avitabile M, Succoio M, Testori A, Cardi | Carcinogenesis | 2020 | 0 |
| Manassantin B shows antiviral activity against coxsackievirus B3 infection by ac [PMID:31253850] | Song JH, Ahn JH, Kim SR, Cho S, Hong EH, | Scientific reports | 2019 | 0 |
| Brain Glucose Metabolism: Integration of Energetics with Function. [PMID:30565508] | Dienel GA | Physiological reviews | 2019 | 0 |
| A ketogenic drink improves brain energy and some measures of cognition in mild c [PMID:31027873] | Fortier M, Castellano CA, Croteau E, Lan | Alzheimer's & dementia : the j | 2019 | 0 |
| Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms an [PMID:28778403] | Koschmieder S, Vetrie D | Seminars in cancer biology | 2018 | 0 |
| Perspectives on oral squamous cell carcinoma prevention-proliferation, position, [PMID:29752860] | Thomson PJ | Journal of oral pathology & me | 2018 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.12 · 2026-04-27
closed · Rounds: 4 · Score: 0.42 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.47 · 2026-04-27
closed · Rounds: 4 · Score: 0.52 · 2026-04-27
closed · Rounds: 4 · Score: 0.72 · 2026-04-27
closed · Rounds: 4 · Score: 0.93 · 2026-04-04
closed · Rounds: 4 · Score: 0.80 · 2026-04-03
closed · Rounds: 4 · Score: 0.90 · 2026-04-03
Hypotheses and analyses mentioning Astrocyte-neuron lactate shuttle in their description or question text
No additional research found