Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Astrocyte Reactivity / A1-A2 Polarization: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| GFAP | participates_in | gene | 0.68 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| GFAP-Positive Reactive Astrocyte Subtype Delineation | 0.754 | Alzheimer's Disease | SEA-AD Gene Expression Profiling — Allen |
| Astrocyte-Mediated Microglial Memory Erasure | 0.677 | - | Neuroinflammation and microglial priming |
| Heterogeneous astrocyte activation states differentially imp | 0.640 | Alzheimer's disease | SEA-AD Single-Cell Analysis: Cell-Type V |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-02 | 5 hypotheses Top: 0.761
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| iPSC-NPC effects on astrocytes in vitro ICH model | exploratory | intracerebral hemorrhage | 0.900 | 0.00 | in vitro ICH cell culture mode | completed | N/A |
| Cognitive impact of TDP-43 pathology in AD patients | clinical | Alzheimer's disease | 0.700 | 0.00 | human patients | completed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Recept [PMID:28709002] | Nabet BY, Qiu Y, Shabason JE, Wu TJ, Yoo | Cell | 2017 | 412 |
| Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655] | Jorstad NL, Close J, Johansen N, Yanny A | Science | 2023 | 186 |
| Independent and interactive contributions of white matter hyperintensities and A [PMID:41906163] | Dario Bachmann; Christoph Gericke; Maha | Alzheimer's research & the | 2026 | 0 |
| Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associate [PMID:41905188] | Cetindag AC, Schipke CG, Esselmann H, Kr | The journal of prevention of A | 2026 | 0 |
| Brain atrophy patterns in anti-IgLON5 disease. [PMID:40650880] | Yogeshwar SM, Bartels F, Grüter T, Muñiz | Brain | 2026 | 0 |
| Biomarkers for Alzheimer's disease across diverse biological domains: an umbrell [PMID:40680830] | Kang J, Son Y, Yim Y, Cho H, Kim J et al | J Adv Res | 2026 | 0 |
| Potential diagnostic markers in Alzheimer's disease: current perspectives and fu [PMID:40911035] | Zheng M, Wang S, Jia J | Neurodegener Dis Manag | 2026 | 0 |
| MAO-B status in alcohol use disorder: a [(11)C]SL25.1188 PET imaging study of pu [PMID:41291188] | Best LM, Truong J, McCluskey T, Meyer JH | Mol Psychiatry | 2026 | 0 |
| Kidney Function, Alzheimer Disease Blood Biomarkers, and Dementia Risk in Commun [PMID:41337685] | Gasparini F, Valletta M, Vetrano DL, Ber | Neurology | 2026 | 0 |
| Obstructive sleep apnea, biomarker profiles, and clinical progression in Parkins [PMID:41499940] | Zhu S, An D, Liu X | Sleep Med | 2026 | 0 |
| The role of astrocytes in Alzheimer's disease: Pathophysiology, biomarkers, and [PMID:41527736] | Abedin MJ, Kastanenka KV | J Alzheimers Dis | 2026 | 0 |
| Association between sleep duration and fluid biomarkers of Alzheimer's disease: [PMID:41610733] | Young VM, Zeynoun J, Ruiz Laza A, Salard | Sleep Med Rev | 2026 | 0 |
| Biomarker-integrated prognostic stagings for Alzheimer's Disease. [PMID:41622252] | Shin D, Lee S, Kim JP, Jang H, Yun J et | Nat Commun | 2026 | 0 |
| Systemic inflammation and its associations in acute moderate-severe Traumatic Br [PMID:41623670] | Li LM, Kodosaki E, Xu CJY, Heslegrave A, | Brain Behav Immun Health | 2026 | 0 |
| Injectable anti-inflammatory, antioxidant supramolecular nanofiber hydrogel for [PMID:41624514] | Liu A, Sheng K, Li H, Zhao X, Zhang X et | Mater Today Bio | 2026 | 0 |
| Time-dependent neurovascular unit dysfunction in ischemic stroke: mechanisms of [PMID:41642667] | Lahariya R, Sinha M, Kumari B, Subramani | Int J Neurosci | 2026 | 0 |
| NRF2 deficit prevents pathologic Tau seeding and spreading in an induced tauopat [PMID:41650822] | López-Sampere Y, Mengod Soler P, Roca-Pe | Redox Biol | 2026 | 0 |
| Integrative Proteomics Reveal Neuroimmune and Dopaminergic Alterations Across th [PMID:41677653] | Majumdar S, Prajapati SK, Dande A, Yata | Cells | 2026 | 0 |
| Prognostic Value of Plasma NfL and GFAP for Conversion to Alzheimer's Disease an [PMID:41703957] | Özkurt Ç, Kelicen-Uğur P | Biomarkers | 2026 | 0 |
| Decoding Alzheimer's disease through down syndrome: insights from a genetically [PMID:41709686] | Russell JK, Schlachetzki Z, Rafii MS | Curr Opin Neurol | 2026 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning Astrocyte Reactivity / A1-A2 Polarization in their description or question text
No additional research found