disease

alpha-synucleinopathies

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about alpha-synucleinopathies: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

0Hypotheses

1Analyses

8Outgoing

4Incoming

0Experiments

1Debates

No summary available yet.

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Disease Info

Associated Genes	APOE
KG Connections	8 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (1)

Knowledge base pages for this entity

alpha-synucleinopathies

disease · 3191 words

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Pathway Diagram

flowchart TD
    alpha_synucleinopathies["alpha-synucleinopathies"]
    Alpha_Synuclein(["Alpha-Synuclein"])
    SNCA(["SNCA"])
    PARKINSON(["PARKINSON"])
    Parkinson_s_Disease["Parkinson's Disease"]
    disease["disease"]
    PARKINSON_S("PARKINSON'S")
    SYNUCLEIN("SYNUCLEIN")

    alpha_synucleinopathies -->|"associated with"| Alpha_Synuclein
    alpha_synucleinopathies -->|"associated with"| SNCA
    alpha_synucleinopathies -->|"associated with"| PARKINSON
    alpha_synucleinopathies -->|"associated with"| Parkinson_s_Disease
    alpha_synucleinopathies -->|"associated with"| disease
    alpha_synucleinopathies -->|"associated with"| PARKINSON_S
    alpha_synucleinopathies -->|"associated with"| SYNUCLEIN

    style alpha_synucleinopathies fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (8)

Target	Relation	Type	Str
Neurodegeneration	causes	phenotype	0.85
PARKINSON	associated_with	gene	0.50
Parkinson's Disease	associated_with	disease	0.50
disease	associated_with	disease	0.50
Alpha-Synuclein	associated_with	protein	0.50
SYNUCLEIN	associated_with	concept	0.50
SNCA	associated_with	gene	0.50
PARKINSON'S	associated_with	concept	0.50

Incoming (4)

Source	Relation	Type	Str
SNCA	causes	gene	0.95
PATHOLOGICAL Α-SYNUCLEIN	biomarker_for	protein	0.90
Alpha-Synuclein	biomarker_for	protein	0.80
APOE	associated_with	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

neurodegeneration | 2026-04-13 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The study shows PSEN2 is essential in cortical and dopaminergic neurons and regu

closed · Rounds: 4 · Score: 0.68 · 2026-04-16

Related Research

Hypotheses and analyses mentioning alpha-synucleinopathies in their description or question text

No additional research found