Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATAXIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ATAXIN1 |
| Protein Family | Ataxin family |
| Function | Under physiological conditions, Ataxin-1 performs essential functions in neuronal development, transcriptional regulation, and cellular homeostasis. |
| Subcellular Localization | to the nucleus of neurons, where it exerts its normal physi |
| Molecular Weight | 87 kDa |
| UniProt ID | P54253 |
| GeneCards | ATAXIN1 |
| Human Protein Atlas | ATAXIN1 |
| HDAC3 (Histone Deacetylase 3) | Modulates gene expression through chromatin remodeling |
| BCL6 | A transcriptional repressor involved in immune function and neuronal development[@serra2006] |
| Wnt/β-catenin signaling | Through interaction with HBP1, Ataxin-1 modulates this developmental pathway |
| DNA damage response | The protein localizes to DNA damage foci and participates in repair mechanisms[@chen2024] |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ATXN1["ATAXIN1 protein"]
PolyQ["Polyglutamine expansion"]
Mutant["Mutant ATXN1"]
AXH["AXH domain"]
Nucleus["Nuclear accumulation"]
Inclusions["Nuclear inclusions"]
Transcription["Transcriptional dysregulation"]
CREB["CREB signaling"]
Chaperones["Molecular chaperones"]
UPS["Ubiquitin-proteasome system"]
Autophagy["Autophagy pathway"]
Purkinje["Purkinje cell death"]
SCA1["Spinocerebellar ataxia type 1"]
Ataxia["Progressive ataxia"]
Neurodegeneration["Neurodegeneration"]
ATXN1 -->|"expansion"| PolyQ
PolyQ -->|"produces"| Mutant
Mutant -->|"nuclear translocation"| Nucleus
AXH -->|"regulates"| Nucleus
Nucleus -->|"forms"| Inclusions
Inclusions -->|"disrupts"| Transcription
Transcription -->|"inhibits"| CREB
Chaperones -->|"refolds"| Mutant
UPS -->|"degrades"| Mutant
Autophagy -->|"clears"| Inclusions
Mutant -->|"toxicity"| Purkinje
Purkinje -->|"causes"| SCA1
SCA1 -->|"manifests as"| Ataxia
SCA1 -->|"leads to"| Neurodegeneration
classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#fff
classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#fff
classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#fff
class ATXN1 central
class Chaperones,UPS,Autophagy protective
class PolyQ,Mutant,Inclusions,Purkinje pathological
class AXH,Transcription,CREB regulatory
class SCA1,Ataxia,Neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ATAXIN1 in their description or question text
No additional research found