Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ASTROGLIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| C3 | expresses | gene | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| C3 | expressed_in | protein | 0.90 |
| Thyroid Hormone | modulates | compound | 0.85 |
| Thyroid Hormone Deficit | causes | process | 0.85 |
| P62 | expressed_in | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Astroglial Gap Junction Coordination via Connexin-43 Phospho | 0.720 | neurodegeneration | Perivascular spaces and glymphatic clear |
| TREM2-Mediated Astroglial Reactivity in Neurodegeneration | 0.600 | neurodegeneration | Gene expression changes in aging mouse b |
| TLR2 Recognition of Gut-Derived Fungal and Bacterial D-Alany | 0.550 | neurodegeneration | How does gut microbiome dysbiosis contri |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Cx43 knockdown effects on mitochondrial transfer | exploratory | osteoarthritis | 0.900 | 0.00 | human bone marrow-derived MSCs | proposed | N/A |
| Confocal imaging of MSC-chondrocyte interactions during mitochondrial | exploratory | osteoarthritis | 0.850 | 0.00 | human bone marrow-derived MSCs | proposed | N/A |
| Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Gap Junction Dysfunction Validation in Parkinson's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| PIEZO channels link mechanical forces to uterine contractions in parturition. [PMID:41231991] | Zhang Y, Kini SA, Mishkanian SA, Yarishk | Science | 2025 | 1 |
| GJA1-20k and Mitochondrial Dynamics. [PMID:35399255] | Shimura D, Shaw RM | Front Physiol | 2022 | 1 |
| Inhibition of connexin43 improves functional recovery after ischemic brain injur [PMID:25988944] | Li X, Zhao H, Tan X, Kostrzewa RM, Du G, | Glia | 2015 | 1 |
| Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline [PMID:41618855] | ["Ying H", "Fan H", "Wang Y", "Jiang R", | Advanced science (Weinheim, Ba | 2026 | 0 |
| Prenatal lipopolysaccharide exposure programs cardiac fibrosis via dysregulating [PMID:41789580] | Wen Y, Yuan Y, Zhang H, Liu Y | Molecular medicine reports | 2026 | 0 |
| The relationship between Connexin 43 (Cx43) and partner protein, human discs lar [PMID:41703342] | ["Scott H", "Dong L", "Stevenson A", "Ma | Cell and tissue research | 2026 | 0 |
| Thermal Adaptation Inhibits the Wnt Signaling Pathway Regulating Autophagy and I [PMID:41889212] | ["Song R", "Zhang Z", "Zhu S", "Fu K", " | Molecular reproduction and dev | 2026 | 0 |
| Identification and validation of ferroptosis-related genes for diabetic nephropa [PMID:41825713] | Duan H, Wang Y, Wang Q, Yan J, Fan X, Wu | European journal of pharmacolo | 2026 | 0 |
| Danggui Sini decoction attenuates intervertebral disc degeneration by regulating [PMID:41812505] | Chen S, Zhou X, Wang W, Zheng Y, Kang R, | International immunopharmacolo | 2026 | 0 |
| Reproductive tissue-derived stromal cells rescue fertility by coupling follicula [PMID:41888633] | ["Borutinskait\u0117 V", "Krastinait\u01 | Stem cells translational medic | 2026 | 0 |
| A Single-Cell Transcriptomic Atlas Elucidates a Microglial Gene Signature Linkin [PMID:41884157] | ["Zhong R", "Yang H", "Li X", "Wang F", | Journal of inflammation resear | 2026 | 0 |
| Essential Role of CD63 in Maintaining Corneal Epithelial Identity in the Human L [PMID:41817143] | ["Sasamoto Y", "Suzuki K", "Sato S", "Le | Investigative ophthalmology & | 2026 | 0 |
| Hypoxia Increases Connexin46 and Connexin43 Levels in KNS-42 Glioblastoma Cells. [PMID:41898710] | Minogue PJ, Beyer EC, Berthoud VM | International journal of molec | 2026 | 0 |
| Cx43 modulates malignant phenotypes in bladder cancer cells via the c-Src/PTEN/F [PMID:41910821] | ["Chi Q", "Xu H", "Li H", "Ma G", "Li X" | Journal of molecular histology | 2026 | 0 |
| SnRNA-seq reveals the ameliorative effects of optimized Xueyu Jingshen formula o [PMID:41720010] | Bai J, Xie N, Hou Y, Yan J, Chen M, Yu S | Phytomedicine : international | 2026 | 0 |
| Transcriptome and alternative splicing analyses uncover immune-centric pathogene [PMID:41911957] | ["Yan W", "Na L", "Tao G", "Jing L", "Yi | Gene | 2026 | 0 |
| De novo NSF mutations cause early infantile epileptic encephalopathy. [PMID:31675180] | ["Suzuki H", "Yoshida T", "Morisada N", | Annals of clinical and transla | 2019 | 0 |
| [Adverse reactions analysis of Aconiti Lateralis Radix Praeparata and mechanism [PMID:30989863] | ["He J", "Wu P", "Dong Y", "Gao R"] | Zhongguo Zhong yao za zhi = Zh | 2019 | 0 |
| Polarity Protein AF6 Controls Hepatic Glucose Homeostasis and Insulin Sensitivit [PMID:31127058] | ["Dai C", "Wang X", "Wu Y", "Xu Y", "Zhu | Diabetes | 2019 | 0 |
| Fast molecular outflow from a dusty star-forming galaxy in the early Universe. [PMID:30190403] | ["Spilker J", "Aravena M", "B\u00e9therm | Science (New York, N.Y.) | 2018 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ASTROGLIA in their description or question text
No additional research found