concept

AMYLOID-BETA ACCUMULATION

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about AMYLOID-BETA ACCUMULATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections

0Hypotheses

2Analyses

5Outgoing

17Incoming

0Experiments

6Debates

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💡 Concept Info

Name	AMYLOID-BETA ACCUMULATION
Key Genes/Proteins	AQP4

Pathway Diagram

graph TD
    AMYLOID_BETA_ACCUMULATION[AMYLOID-BETA ACCUMULATION]
    AMYLOID_BETA_ACCUMULATION -->|contributes to| Alzheimer_Disease[Alzheimer Disease]
    AMYLOID_BETA_ACCUMULATION -->|contributes to| Alzheimer_s_Disease[Alzheimer's Disease]
    AMYLOID_BETA_ACCUMULATION -->|contributes to| Sulfatide_Loss[Sulfatide Loss]
    Apoe4[Apoe4] -->|contributes to| AMYLOID_BETA_ACCUMULATION
    Autophagy_Clearance_Failure[Autophagy Clearance Failure] -->|contributes to| AMYLOID_BETA_ACCUMULATION
    Glymphatic_System_Impairment[Glymphatic System Impairment] -->|contributes to| AMYLOID_BETA_ACCUMULATION
    APOE[APOE] -->|promotes| AMYLOID_BETA_ACCUMULATION
    Complement_System[Complement System] -->|contributes to| AMYLOID_BETA_ACCUMULATION
    APP_PSEN1[APP/PSEN1] -->|causes| AMYLOID_BETA_ACCUMULATION
    SIK2[SIK2] -.prevents.-> AMYLOID_BETA_ACCUMULATION
    GLYMPHATIC_SYSTEM_IMPAIRMENT[GLYMPHATIC SYSTEM IMPAIRMENT] -->|contributes to| AMYLOID_BETA_ACCUMULATION
    TET2[TET2] -->|inhibits| AMYLOID_BETA_ACCUMULATION
    AQP4[AQP4] -->|regulates| AMYLOID_BETA_ACCUMULATION

Outgoing (5)

Target	Relation	Type	Str
Alzheimer's Disease	causes	disease	0.95
Alzheimer's Disease	contributes_to	disease	0.95
Alzheimer Disease	contributes_to	disease	0.95
Alzheimer's Disease	contributes_to	disease	0.90
Sulfatide Loss	contributes_to	phenotype	0.80

Incoming (17)

Source	Relation	Type	Str
Apoe4	contributes_to	biomarker	0.90
Autophagy Clearance Failure	contributes_to	process	0.90
APOE	promotes	gene	0.90
31690660	increased	paper	0.90
APP/PSEN1	causes	gene	0.90
Complement System	contributes_to	pathway	0.90
SIK2	prevents	gene	0.90
Glymphatic System Impairment	contributes_to	process	0.90
GLYMPHATIC SYSTEM IMPAIRMENT	contributes_to	process	0.89
AQP4	regulates	protein	0.88
TET2	inhibits	gene	0.88
TET2 Reduction	contributes_to	process	0.87
Glymphatic System	associated_with	process	0.80
APOE	therapeutic_target	gene	0.75
sleep deprivation	causes	process	0.70
lipid raft remodeling	prevents	process	0.70
CYP46A1	reduces	gene	0.70