entity

AGA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AGA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

30Hypotheses

0Analyses

1Outgoing

1Incoming

3Experiments

0Debates

No AI portrait yet

Wiki Pages (4)

Knowledge base pages for this entity

RRAGA — Ras-Related GTP Binding A

gene · 2350 words

→

NIAGADS — National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site

institution · 2250 words

→

NAGA - Alpha-N-Acetylgalactosaminidase

gene · 1171 words

→

NAGA Protein - Alpha-N-Acetylgalactosaminidase

protein · 633 words

→

Outgoing (1)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00

Incoming (1)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SNCA conformer propagation across PD, DLB, and MSA	0.820	multi	Cross-disease neurodegeneration mechanis
Closed-loop tACS targeting EC-II PV interneurons to suppress	0.811	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.797	Alzheimer's disease	Circuit-level neural dynamics in neurode
SIRT1/PGC-1α Axis Activation to Preserve Mitochondrial Resil	0.778	neurodegeneration	Gut Microbiome Analysis in Parkinson's D
Exosomal SNCA Propagation from Lysosome-Compromised Neurons	0.777	neurodegeneration	-

cGAS-STING Pathway Hyperactivation Mediates Tau Propagation	0.760	neurodegeneration	Gap 006 analysis (archived stub)
Synaptic Vesicle Cycle Hijacking: Shared Convergent Mechanis	0.760	neurodegeneration	-
Closed-loop tACS targeting EC-II SST interneurons to block t	0.752	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur	0.748	Alzheimer's disease	Circuit-level neural dynamics in neurode
SASP-Secreted MMP-9 from Senescent Microglia Generates Patho	0.713	ALS	What are the mechanisms by which microgl
Closed-loop transcranial focused ultrasound targeting EC-II	0.712	Alzheimer's disease	Circuit-level neural dynamics in neurode
Noradrenergic-Tau Propagation Blockade	0.711	neurodegeneration	Sleep disruption as cause and consequenc
Granzyme B Inhibition with Serpina3n to Preserve Axonal Inte	0.698	neuroimmunology	Do CXCL10-recruited CD8+ T cells provide
Rab27A/B-mediated exosomal tau secretion from microglia driv	0.690	neurodegeneration	Which tau propagation mechanism predomin
Microglial NOX2 establishes an inflammatory ROS propagation	0.680	neurodegeneration	What mechanisms drive the self-amplifyin
A downstream LRRK2-Rab10-JIP4 lysosomal stress loop promotes	0.680	neurodegeneration	Do pathogenic LRRK2 mutations amplify vo
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A	0.669	neurodegeneration	What are the mechanisms by which gut mic
CDK5 Inhibition at Presynaptic Terminals Prevents Activity-D	0.640	neurodegeneration	Investigate prion-like spreading of tau
Autophagosome-Lysosome Fusion Defects as Primary Driver of α	0.630	neurodegeneration	Gap 006 analysis (archived stub)
APOE ε4-driven microglial lipid handling as proximal driver	0.626	neurodegeneration	Non-Neuronal Transcriptional Changes Pre
Vagal Afferent Microbial Signal Modulation	0.621	neurodegeneration	What are the mechanisms by which gut mic
H7: Enteric Nervous System Alpha-Synuclein Propagation Block	0.620	neurodegeneration	How does engineered C. butyricum cross t
CDK5 Inhibition Blocks Activity-Dependent Tau Propagation	0.620	neurodegeneration	Test Preregistration Analysis
Cell-state stratification is required to resolve Non-Neurona	0.612	neurodegeneration	Non-Neuronal Transcriptional Changes Pre
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	Non-Neuronal Transcriptional Changes Pre
DAPK1 Inhibition as Dual-Mechanism Neuroprotection Against T	0.604	neurodegeneration	Should microtubule-stabilizing drugs be
LRP1-mediated tau uptake disruption as an initiator of early	0.604	neurodegeneration	AD Master Plan preregistration: LRP1
Closed-loop tACS targeting EC-II PV interneurons to enhance	0.596	Alzheimer's disease	Circuit-level neural dynamics in neurode
Exosomal α-Synuclein as an Interneuronal Propagation Vector	0.595	neurodegeneration	Legacy Pre-Pipeline Hypothesis Import
TBK1 Loss Triggers Astrocyte-to-Neuron Senescence Propagatio	0.000	ALS	What are the mechanisms by which microgl

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Epigenetic clocks association with brain aging patterns in older women	exploratory	cognitive impairment and demen	0.900	human patients	proposed	N/A
PGC-1α knockout analysis of PV+ interneuron maturation	validation	neurodevelopmental disorders	0.850	knockout mice	proposed	N/A
PV+ interneuron subtype diversification analysis	exploratory	neurodevelopmental disorders	0.750	mouse cortical PV+ interneuron	proposed	N/A

Related Papers (18)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN [PMID:38712164]	Unknown		2025
The R136S mutation in the APOE3 gene confers resilience against tau pathology vi [PMID:40555238]	Unknown		2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Anti-herpetic tau preserves neurons via the cGAS-STING-TBK1 pathway in Alzheimer [PMID:39753133]	Hyde VR, Zhou C, Fernandez JR, Chatterje	Cell reports	2025
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senes [PMID:39353433]	Carling GK, Fan L, Foxe NR, Norman K, Wo	Neuron	2024
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667]	Zhang D, Zhang W, Ming C, Gao X, Yuan H,	Neuron	2024
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117]	Balusu S, De Strooper B	Acta neuropathologica	2024
Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflam [PMID:34782623]	["Jin Meihua", "Shiwaku Hiroki", "Tanaka	Nature communications	2021
Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890]	Burillo J, Marqués P, Jiménez B, Gonzále	Cells	2021
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169]	["Oakley, Holly", "Cole, Sarah L", "Loga	The Journal of neuroscience :	2006
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773]	["Hardy, John", "Selkoe, Dennis J"]	Science (New York, N.Y.)	2002
Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple sys [PMID:9682846]	Unknown	Neuroscience letters	1998
Mutation in the alpha-synuclein gene identified in families with Parkinson's dis [PMID:9197268]	Unknown	Science (New York, N.Y.)	1997
Alpha-synuclein in Lewy bodies. [PMID:9278044]	Unknown	Nature	1997

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AGA in their description or question text

cGAS-STING Pathway Hyperactivation Mediates Tau Propagation

Score: 0.760 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The cGAS-STING (cyclic GMP-AMP synthase - stimulator of interferon genes) pathway

Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and r

Score: 0.752 · Alzheimer's disease · 2026-04-05

## Mechanistic Overview Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and restore perforant

Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma

Score: 0.748 · Alzheimer's disease · 2026-04-05

## Mechanistic Overview Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma gating and bloc

SASP-Secreted MMP-9 from Senescent Microglia Generates Pathological TDP-43 C-Ter

Score: 0.713 · ALS · 2026-04-26

The hypothesis proposes that MMP-9 (matrix metalloproteinase-9), secreted via the senescence-associated secretory phenot

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to

Score: 0.712 · Alzheimer's disease · 2026-04-07

## Mechanistic Overview Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to prevent tau prop

Noradrenergic-Tau Propagation Blockade

Score: 0.711 · neurodegeneration · 2026-04-02

## Mechanistic Overview Noradrenergic-Tau Propagation Blockade starts from the claim that modulating ADRA2A within the d

Granzyme B Inhibition with Serpina3n to Preserve Axonal Integrity Against Cytoto

Score: 0.698 · neuroimmunology · 2026-04-15

## Mechanistic Overview Granzyme B Inhibition with Serpina3n to Preserve Axonal Integrity Against Cytotoxic Attack start

Rab27A/B-mediated exosomal tau secretion from microglia drives frontal cortex pr

Score: 0.690 · neurodegeneration · 2026-04-21

## Mechanistic Overview Rab27A/B-mediated exosomal tau secretion from microglia drives frontal cortex propagation at Bra

Microglial NOX2 establishes an inflammatory ROS propagation loop around vulnerab

Score: 0.680 · neurodegeneration · 2026-04-25

Dying or stressed neurons release alpha-synuclein and DAMPs that activate microglia, which then generate superoxide thro

A downstream LRRK2-Rab10-JIP4 lysosomal stress loop promotes alpha-synuclein rel

Score: 0.680 · neurodegeneration · 2026-04-24

Even if G2019S mainly elevates the kinase floor, that increase may still become pathogenic by pushing a thresholded down

Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain Anti-Inflammatory Com

Score: 0.669 · neurodegeneration · 2026-04-02

## Mechanistic Overview Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain Anti-Inflammatory Communication start

CDK5 Inhibition at Presynaptic Terminals Prevents Activity-Dependent Tau Release

Score: 0.640 · neurodegeneration · 2026-04-22

## **Molecular Mechanism and Rationale** The cyclin-dependent kinase 5 (CDK5) represents a critical regulatory node in

Autophagosome-Lysosome Fusion Defects as Primary Driver of α-Synuclein Propagati

Score: 0.630 · neurodegeneration · 2026-04-22

## **Molecular Mechanism and Rationale** The autophagosome-lysosome fusion process represents a critical checkpoint in

APOE ε4-driven microglial lipid handling as proximal driver in Non-Neuronal Tran

Score: 0.626 · neurodegeneration · 2026-04-28

APOE ε4-driven microglial lipid handling should produce a measurable proximal phenotype before late disease pathology. T