Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about adra2c: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ADRA2C |
| Full Name | Alpha-2C Adrenergic Receptor |
| Chromosome | 4p16.3 |
| Primary Expression | the central nervous system and peripheral tissues, playing crucial roles in regulating norepinephrine signaling, autonomic function, and stress respon |
| Amino Acids | 462 aa |
| Pathways | MAPK Pathway |
| UniProt ID | [P21917](https://www.uniprot.org/uniprot/P21917) |
| Ensembl ID | ENSG00000141449 |
| GeneCards | ADRA2C |
| Human Protein Atlas | ADRA2C |
| 7 TM Helices (TM1-TM7) | Canonical GPCR structure forming the ligand-binding pocket |
| Disulfide Bond | Conserved cysteine in extracellular loop 2 that stabilizes receptor structure |
| N-linked Glycosylation Sites | N-terminal extracellular domain for proper folding and trafficking |
| Conserved Motifs | DRY motif in TM3 for G protein coupling, NPxxY in TM7 for activation |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["Regulatory elements"] --> B["adra2c gene"]
B --> C["mRNA transcript"]
C --> D["Protein product"]
D --> E["Cellular function"]
E --> F["Disease relevance"]
B --> G["Variant effects"]
G --> F
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
class B gene
class D protein| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning adra2c in their description or question text
No additional research found