entity

AD Pathology

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AD Pathology: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

20Connections

2Hypotheses

2Analyses

0Outgoing

20Incoming

0Experiments

3Debates

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Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (20)

Source	Relation	Type	Str
Aβ42:Aβ40 Ratio	biomarker_for	biomarker	0.93
Amyloid Probability Score 2	biomarker_for	biomarker	0.93
MAPT	associated_with	protein	0.92
GFAP	indicates	protein	0.90
21098403	suggests	paper	0.90
41542441	does not result in	paper	0.90
29552443	is less evident in NHD than	paper	0.90
29552443	is less evident in	paper	0.90
39272998	has been proven to be a major contributor to	paper	0.90
39272998	is a major contributor to	paper	0.90
TREM2	regulates	protein	0.85
Excitatory Neurons	associated_with	cell_type	0.82
Cognitive Resilience	associated_with	phenotype	0.80
GFAP	regulates	gene	0.75
TREM2 deletion	causes	gene	0.70
synaptic dysfunction	causes	mechanism	0.70
29499767	could be mechanistically important in	paper	0.60
41542441	no reduction in	paper	0.60
31392412	spreads via	paper	0.60
41942760	associated with	paper	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE4 lipid dysregulation and synaptic phagocytosis as early	0.604	neurodegeneration	AD Master Plan preregistration: APOE
Gut dysbiosis-driven monocyte reprogramming toward NETotic p	0.380	Alzheimer's disease	Systemic immune profiling and peripheral