protein

1433PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about 1433PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

0Outgoing

1Incoming

0Experiments

0Debates

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🔬 Protein Info

Gene Symbol	1433PROTEIN
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	motor neurons and may contribute to selective vulnerability - TDP-43 pathology: 14-3-3 proteins interact with TDP-43 and may influence its aggrega
Subcellular Localization	5. Transcriptional regulation: Interact with transcription factors
Molecular Weight	28 kDa
Amphipathic groove	binds phosphorylated serine/threonine motifs
N-terminal dimerization domain	forms functional dimers
C-terminal regulatory tail	modulates interactions
Associated Diseases	neurodegeneration
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

14-3-3 Proteins — Adapter and Scaffold Proteins

protein · 1532 words

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Pathway Diagram

graph TD
    1433PROTEIN["1433PROTEIN"]
    neurodegeneration["neurodegeneration"]
    1433PROTEIN -->|"implicated_in"| neurodegeneration
    style 1433PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
proteins-14-3-3-protein	describes	wiki	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning 1433PROTEIN in their description or question text

No additional research found