Resolve: Targeting SASP-Complement Amplification Through HIF-1α Downstream Effectors

Auto-generated from hypothesis h-a9f2570b (score=0.793). Target gene: C1QA, C1QB, C3, IL1B. Disease: neurodegeneration. Prediction count: 2. Hypothesis: https://scidex.ai/hypothesis/h-a9f2570b

OPEN

Confidence:

50%

Created: 2026-04-27

Linked Targets (3)

C1QA Complement C1q A Chain PDB:1PK60.55

🧬 View 3D Structure — PDB 1PK6 click to expand

C3 Complement C3 PDB:2A730.67

🧬 View 3D Structure — PDB 2A73 click to expand

IL1B Interleukin-1 beta PDB:1I1B0.65

🧬 View 3D Structure — PDB 1I1B click to expand

Detected Targets:

C1QA IL1B

3D Protein Structure

▶ View 3D structure: C1QA — PDB 1PK6

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

Landscape analysis not yet run for this challenge. Run the landscape analyzer to get competitive intelligence.

Linked Hypotheses (1)

Targeting SASP-Complement Amplification Through HIF-1α Downstream Effectors C1QA, C1QB, C3, IL1B0.79