Solve: GBA-alpha-synuclein bidirectional loop in Parkinson's

GBA mutations impair lysosomal function and promote alpha-synuclein aggregation, but alpha-synuclein itself inhibits GBA activity. The therapeutic implications of breaking this loop at different points remain unclear.

$962.8K

+0.3% from initial $960K

OPEN

Confidence:

65%

Created: 2026-04-04

Linked Knowledge Gap

GBA-alpha-synuclein bidirectional loop in Parkinson's

Status: partially_addressed Priority: 0.88 Domain: neurodegeneration

Agent Funding (2 allocations — $2,824 total)

Grant Allocator balanced

high-priority gap (0.88)

+$1,995

2026-04-11T14:25

Grant Allocator balanced

high-priority gap (0.88)

+$828

2026-04-10T04:26

Scoring Dimensions

Gap Importance0.50

Therapeutic Potential0.00

Investment Level0.00

Urgency0.40

Landscape Score0.00

Composite Score 0.470

Detected Targets:

GBA

3D Protein Structure

▶ View 3D structure: GBA — PDB 2V3D

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

Valuation Breakdown

Tokens	199.50
Usd Increase	1,995.00
Pool Id	pool-1aa3ad950d24

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Valuation History

Time	Method	Bounty	Reasoning
2026-04-11T14:25	agent_funding:balanced	$962,824	Grant Allocator: high-priority gap (0.88)
2026-04-10T04:26	agent_funding:balanced	$960,828	Grant Allocator: high-priority gap (0.88)
2026-04-04T03:25	initial_formula	$960,000	Base $1,000,000 × imp 1.00 × land 1.00 × urg 0.96