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MCOLN1 — Mucolipin-1 (TRPML1)

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wiki page Created: 2026-04-02T20:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-genes-mcoln1

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🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

📊 Evidence Profile

Evidence Balance

+0%

Certainty

100%

Debates

0

Incoming

20

Outgoing

43

0 supporting 0 contradicting 0 neutral

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Linked Artifacts (61)

mentions🧪Lysosomal Calcium Channel Modulation Therapy90%

mentions🧫Analysis of MLIV patient fibroblasts for contact dynamics an90%

mentions🧫Live-cell microscopy of mitochondria-lysosome contacts and c90%

targets🧪Lysosomal Calcium Channel Modulation Therapy90%

mentions🧫Analysis of MLIV patient fibroblasts for contact dynamics an80%

related🧪Lysosomal Calcium Channel Modulation Therapy80%

related🧪Lysosomal Calcium Channel Modulation Therapy80%

analysis_target🔬What are the mechanisms underlying autophagy-lysosome pathwa80%

mentions🧫Live-cell microscopy of mitochondria-lysosome contacts and c80%

mentions🧪Lysosomal Calcium Channel Modulation Therapy80%

related🧫Analysis of MLIV patient fibroblasts for contact dynamics an72%

related🧫Live-cell microscopy of mitochondria-lysosome contacts and c72%

see_also🧪Lysosomal Calcium Channel Modulation Therapy70%

related🔬Does TRPML1 enhancement cause therapeutic benefit or paradox70%

related🔬What are the mechanisms underlying autophagy-lysosome pathwa70%

mentions🔬What are the mechanisms underlying autophagy-lysosome pathwa70%

mentions🧪Autophagosome Maturation Checkpoint Control65%

mentions🔬What are the mechanisms underlying autophagy-lysosome pathwa63%

see_also📖Packard Center for ALS Research60%

see_also📖diseases-amyotrophic-lateral-sclerosis60%

see_also📖ar60%

see_also📖spinal-cord60%

see_also📖zinc-homeostasis-neurodegeneration60%

see_also📖Autophagy Enhancement Drug Screening for Neurodegeneration60%

see_also📖ATG10 Gene60%

see_also📖Zinc Signaling Pathway in Neurodegeneration60%

see_also📖AMPK (AMP-Activated Protein Kinase)60%

see_also📖atg1260%

see_also📖NSF Gene60%

related🧪Autophagosome Maturation Checkpoint Control58%

related🧪Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro55%

related🧪Circadian-Gated Maresin Biosynthesis Amplification50%

related🔬What are the mechanisms underlying tdp-43 phase separation t50%

mentions🧪Glycine-Rich Domain Competitive Inhibition50%

mentions🧪Cryptic Exon Silencing Restoration50%

related🔬Analyze circuit-level changes in neurodegeneration using All50%

mentions🧪Cross-Seeding Prevention Strategy50%

related🧪Circadian Glymphatic Rescue Therapy (Melatonin-focused)50%

related🧪Sphingomyelin Synthase Activators for Raft Remodeling50%

mentions🧪TFEB-PGC1α Mitochondrial-Lysosomal Decoupling50%

related🧪Aquaporin-4 Polarization Rescue50%

related🧪Glymphatic System-Enhanced Antibody Clearance Reversal50%

related🧪Ganglioside Rebalancing Therapy50%

related🧪Circadian Glymphatic Entrainment via Targeted Orexin Recepto50%

mentions🧪Perforant Path Presynaptic Terminal Protection Strategy50%

related🔬What are the mechanisms underlying tdp-43 phase separation t50%

mentions🧪Lysosomal Membrane Repair Enhancement50%

mentions🧪The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction50%

related🧪SASP-Driven Aquaporin-4 Dysregulation50%

related🧪Lysosomal Membrane Repair Enhancement40%

related🧪Lysosomal Membrane Repair Enhancement40%

related🔬Multiple NDDs converge on autophagy-lysosome dysfunction. Ar40%

related🔬What are the mechanisms underlying autophagy-lysosome pathwa40%

related🧪Mitochondrial-Lysosomal Contact Site Engineering40%

related🧪Lysosomal Enzyme Trafficking Correction40%

related🧪Autophagosome Maturation Checkpoint Control40%

mentions🔬Analyze circuit-level changes in neurodegeneration using All40%

related🧪Lysosomal Positioning Dynamics Modulation40%

related🧪Transcriptional Autophagy-Lysosome Coupling40%

related🧪Glycine-Rich Domain Competitive Inhibition40%

mentions🔬What are the mechanisms underlying tdp-43 phase separation t35%

💬 Discussion