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entities-gba

wiki page Created: 2026-04-02T17:01:41 By: crosslink-v2 Quality: 50% ✓ SciDEX ID: wiki-entities-gba

🌍 Provenance Graph 1 nodes, 0 edges

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📊 Evidence Profile

Evidence Balance

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Certainty

100%

Debates

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Outgoing

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Linked Artifacts (106)

mentions🧫Validate Mitochondria-Lysosome Contact Site Dysfunction in P90%

mentions🔬Analysis question not specified75%

mentions🔬How to break the GBA-alpha-synuclein bidirectional loop for 75%

related🧫Cytochrome Therapeutics70%

mentions🧫Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio70%

mentions🧫Prodromal Parkinson's Disease Biomarker Development — E70%

related🧫Cytochrome Therapeutics70%

mentions🧫DLB Treatment Response Biomarkers — Predicting Cholinesteras70%

mentions🧫Validate Mitochondria-Lysosome Contact Site Dysfunction in P70%

mentions🧫DNA Damage Repair Deficiency Validation Study in Parkinson&#70%

mentions🧫Genetic Risk Modifiers in DLB Phenotype70%

mentions🧫LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne70%

mentions🧫GLP-1 Agonist Responder Prediction Study — Precision Medicin70%

mentions🧫Experiment: Multi-Ethnic PD GWAS70%

mentions🧫MLCS Quantification in Parkinson's Disease70%

mentions🧫Autophagy Enhancement Drug Screening for Neurodegeneration70%

mentions🧫Synaptic Vesicle Trafficking Dysfunction Validation in Parki70%

related🔬Analysis question not specified67%

related🧫Experiment: Multi-Ethnic PD GWAS63%

see_also📖Aging vs Neurodegeneration: Mechanistic Comparison Matrix60%

see_also📖VPS11 — Vacuolar Protein Sorting 1160%

see_also📖HEXA Gene - Hexosaminidase Alpha60%

see_also📖DDX1 Gene60%

see_also📖TMEM175 Protein60%

see_also📖TMEM175 Lysosomal Modulation Therapy60%

see_also📖WIPI1 Gene60%

see_also📖scn2a60%

see_also📖RAB29 — RAS-Related Protein Rab-2960%

see_also📖ddc60%

see_also📖RALB Gene - RAS-Related Protein Ral-B60%

see_also📖Accelerating Medicines Partnership for Alzheimer's Dise60%

see_also📖HEXA (Redirect)60%

see_also📖proteins-vps13d-protein60%

see_also📖Lysosomal Dysfunction in Progressive Supranuclear Palsy60%

see_also📖ABCD3 Gene60%

see_also📖DOCK2 Gene60%

see_also📖ABCA7 (Redirect)60%

see_also📖Nuclear Receptor Related 1 (NURR1)60%

see_also📖VPS13D Gene60%

see_also📖NRXN1 Gene60%

see_also📖GNB4 Gene — G Protein Subunit Beta 460%

see_also📖WDFY3 Gene60%

see_also📖CELF4 — CUGBP Elav-Like Family Member 460%

see_also📖Autophagy-Lysosomal Pathway60%

see_also📖DCTN2 Protein - Dynactin Subunit 260%

see_also📖GBAP160%

see_also📖VPS13D Protein60%

see_also📖NURR1 Gene60%

see_also📖SCN8A Gene - Nav1.660%

see_also📖HEXB Gene - Hexosaminidase Beta60%

see_also📖SCN4A Gene60%

see_also📖GNAI3 — G Protein Subunit Alpha I360%

see_also📖TMEM175 Protein60%

see_also📖PSMB960%

see_also📖OGDH — Oxoglutarate Dehydrogenase60%

see_also📖bsn60%

see_also📖Lysosomal Dysfunction in Neurodegeneration60%

see_also📖TMEM175 Gene60%

see_also📖SLC17A5 Gene60%

see_also📖AKT1 Gene60%

see_also📖pik3cb60%

see_also📖LIPA Gene60%

see_also📖WIPI1 Protein60%

see_also📖adam1060%

see_also📖Actin Cytoskeleton Dynamics in Neurodegeneration60%

see_also📖SCARB2 Gene60%

see_also📖SUMF1 Gene60%

see_also📖gnptab60%

see_also📖ACTB Gene60%

see_also📖DCTN2 - Dynactin Subunit 260%

see_also📖PILRB Gene60%

mentions🧪Lysosomal Positioning Dynamics Modulation50%

mentions🧪Mitochondrial Transfer Pathway Enhancement50%

mentions🧪APOE Isoform Expression Across Glial Subtypes50%

mentions🧪Phase-Separated Organelle Targeting50%

mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%

mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%

mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%

mentions🧪Competitive APOE4 Domain Stabilization Peptides50%

mentions🧪TREM2-mediated microglial tau clearance enhancement50%

mentions🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%

mentions🧪Metabolic Circuit Breaker via Lipid Droplet Modulation50%

mentions🧪Selective Acid Sphingomyelinase Modulation Therapy50%

mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%

mentions🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors50%

mentions🧪RNA Granule Nucleation Site Modulation50%

mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%

mentions🧪Stress Granule Phase Separation Modulators50%

mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%

entities-gba

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