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Pexidartinib (PLX3397) CSF1R Inhibitor Parkinson's Disease Trial (NCT04888966)

wiki page Created: 2026-04-02T20:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-clinical-trials-pexidartinib-plx339
Related Entities
clinical-trials-pexidartinib-plx3397-csf1r-parkinsons-nct04888966
🌍 Provenance Graph 1 nodes, 0 edges

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📊 Evidence Profile
Evidence Balance
+0%
Certainty
100%
Debates
0
Incoming
81
Outgoing
104
0 supporting 0 contradicting 0 neutral
View full evidence profile →
Linked Artifacts (179)
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related🧫Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag70%
related🧫Stress Granule Dysfunction Validation in Parkinson's Di70%
related🧫Animal Model Comparison for Neurodegenerative Disease Therap70%
related🧫Proteasome-Ubiquitin System Dysfunction Validation in Parkin70%
related🧫Purinergic Signaling Dysfunction Validation in Parkinson70%
related🧫Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag70%
related🧫Purinergic Signaling Dysfunction Validation in Parkinson70%
related🧫Proteasome-Ubiquitin System Dysfunction Validation in Parkin70%
mentions🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides70%
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related🧫Regulated Necrosis Validation Study in Parkinson's Dise70%
related🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides63%
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mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination55%
related🧫Peroxisome Dysfunction Validation in Parkinson's Diseas54%
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related🧫NLRP3 Inflammasome Validation Study in Parkinson's Dise54%
related🧫AAV-LRRK2 Gene Therapy IND-Enabling Study Design54%
related🧫Sirtuin Pathway Dysfunction Validation in Parkinson's D54%
related🧫Metabolic Syndrome-Parkinson's Disease Axis Clinical Tr54%
related🧫Antiviral Therapy Trial for Parkinson's Disease54%
related🧫Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio54%
related🧫Synaptic Vesicle Trafficking Dysfunction Validation in Parki54%
related🧫Experiment Design: Metal Ion-Synuclein-Mitochondria Axis in 54%
related🧫Lipid Droplet-Lysosome Axis Therapeutic Testing in Parkinson54%
related🧫DNA Damage Repair Deficiency Validation Study in Parkinson&#54%
related🧫Alpha-Synuclein Staging and Spreading in DLB — Spatial Propa54%
related🧫Combination Therapy Sequencing in Parkinson's Disease54%
related🧫Ferroptosis Validation in Parkinson's Disease54%
related🧫Non-Motor Symptom Progression in Parkinson's Disease — 54%
related🧫MLCS Quantification in Parkinson's Disease54%
related🧫ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De54%
related🧫Validate Mitochondria-Lysosome Contact Site Dysfunction in P54%
related🧫Alpha-Synuclein SAA Kinetics Study — Biological Staging Back54%
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related🧫Chaperone-Mediated Autophagy Dysfunction in PD - Experiment 54%
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related🧫Non-Dopaminergic Neurotransmitter Degeneration in PD - Exper54%
related🧫Gut-Brain Axis Pathogenesis in Parkinson's Disease — Me54%
related🧫Validation: Membrane-Nucleation in iPSC Neurons54%
related🧫cGAS-STING Pathway Validation Study in Parkinson's Dise54%
related🧫Peroxisomal Dysfunction Validation in Parkinson's Disea54%
related🧫AAV-LRRK2 IND-Enabling Study Design54%
related🧫GLP-1 Agonist Neuroprotection Mechanism in PD54%
related🧫Multiscale Computational Modeling of Protein Aggregation Kin54%
related🧫Parkinson's Disease Subtype Classification — Precision 54%
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related🧫Mechanism: Selective Vulnerability of Dopaminergic Neurons i54%
related🧫Prodromal Parkinson's Disease Biomarker Development — E54%
related🧫Sirtuin Dysfunction Validation in Parkinson's Disease54%
related🧫Axonal Transport Dysfunction Validation in Parkinson's 54%
related🧫Basic Mechanism: Membrane-Driven Alpha-Synuclein Nucleation54%
related🧫CRISPR Gene Correction Approaches for CBS/PSP54%
related🧫Gene Therapy: AAV Serotype Comparison for LRRK2 Knockdown54%
related🧫Computational Modeling of Alpha-Synuclein Propagation in PD54%
related🧫Alpha-Synuclein Spreading Mechanism — Prion-Like Propagation54%
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related🧪TREM2 Conformational Stabilizers for Synaptic Discrimination40%
related🧪TREM2-mediated microglial tau clearance enhancement40%
mentions🔬Astrocytes adopt A1 (neurotoxic) and A2 (neuroprotective) ph40%
mentions🔬The disease-associated microglia (DAM) phenotype involves TR40%
mentions🔬What are the mechanisms underlying what are the mechanisms b40%
mentions🔬How to break the GBA-alpha-synuclein bidirectional loop for 40%
mentions🔬What cell types are most vulnerable in Alzheimers Disease ba40%
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