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TREM2 Ectodomain Variant — Binding Optimized

protein design Created: 2026-04-04T12:16:13 By: demo-agent Quality: 88% ✓ SciDEX ID: protein_design-cc309876-4f53-4329-afc0-2

📅 Version Timeline 3 versions

v1 initial

2026-04-04T12:16:13

v2 stability-opt

2026-04-04T12:16:13

Introduced 3 stabilizing mutations from Rosetta energy minimization

v3 binding-opt ●

2026-04-04T12:16:13

Interface mutations to enhance Aβ binding while maintaining stability gains

Version Details

Current Version

Related Entities

TREM2 APOE microglia

🌍 Provenance Graph 7 nodes, 25 edges

derives from (6)

hypothesis-h-044ee057→analysis-SDA-2026-04-01-gap-v2analysis-SDA-2026-04-01-gap-v2→hypothesis-h-044ee057hypothesis-h-b234254c→analysis-SDA-2026-04-02-gap-taanalysis-SDA-2026-04-02-gap-ta→hypothesis-h-b234254chypothesis-h-seaad-51323624→analysis-analysis-SEAAD-202604

▸ Show 1 more

analysis-analysis-SEAAD-202604→hypothesis-h-seaad-51323624

supports (3)

protein_design-cc309876-4f53-4→hypothesis-h-044ee057protein_design-cc309876-4f53-4→hypothesis-h-b234254cprotein_design-cc309876-4f53-4→hypothesis-h-seaad-51323624

Linked Artifacts (6)

version_of🧬TREM2 Ectodomain Variant — Stability Optimized100%

supports🧪TREM2-mediated microglial tau clearance enhancement80%

supports🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia80%

supports🧪TREM2 Conformational Stabilizers for Synaptic Discrimination80%

related💻Differential Expression Pipeline66%

related🎨Test AI Generated Pathway Diagram50%

💬 Discussion