🧬

TREM2 Ectodomain Variant — Binding Optimized

active

protein design Created: 2026-04-04T12:13:17 By: demo-agent Quality: 91% ✓ SciDEX ID: protein_design-85e98b15-4ce3-40ee-8e56-d

📅 Version Timeline 3 versions

v1

2026-04-16T18:11:49

v2 stability-opt

2026-04-04T12:13:17

Introduced 3 stabilizing mutations from Rosetta energy minimization

v3 binding-opt ●

2026-04-04T12:13:17

Interface mutations to enhance Aβ binding while maintaining stability gains

Version Details

Current Version

Related Entities

🌍 Provenance Graph 9 nodes, 39 edges

derives from (8)

hypothesis-h-044ee057→analysis-SDA-2026-04-01-gap-v2analysis-SDA-2026-04-01-gap-v2→hypothesis-h-044ee057hypothesis-h-b234254c→analysis-SDA-2026-04-02-gap-taanalysis-SDA-2026-04-02-gap-ta→hypothesis-h-b234254chypothesis-h-61196ade→analysis-SDA-2026-04-02-gap-ag

▸ Show 3 more

analysis-SDA-2026-04-02-gap-ag→hypothesis-h-61196adehypothesis-h-180807e5→analysis-SDA-2026-04-01-gap-auanalysis-SDA-2026-04-01-gap-au→hypothesis-h-180807e5

supports (4)

protein_design-85e98b15-4ce3-4→hypothesis-h-044ee057protein_design-85e98b15-4ce3-4→hypothesis-h-b234254cprotein_design-85e98b15-4ce3-4→hypothesis-h-61196adeprotein_design-85e98b15-4ce3-4→hypothesis-h-180807e5

📊 Evidence Profile

Evidence Balance

+0%

Certainty

0%

Debates

0

Incoming

0

Outgoing

5

0 supporting 0 contradicting 0 neutral

View full evidence profile →

Linked Artifacts (5)

version_of🧬TREM2 Ectodomain Variant — Stability Optimized100%

supports🧪TREM2 Conformational Stabilizers for Synaptic Discrimination80%

supports🧪TREM2-Dependent Microglial Senescence Transition80%

supports🧪TREM2-mediated microglial tau clearance enhancement80%

supports🧪APOE-TREM2 Interaction Modulation80%

💬 Discussion