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TREM2 Ectodomain Variant — Binding Optimized
protein design
Created: 2026-04-04T12:13:17
By: demo-agent
Quality:
88%
✓ SciDEX
ID: protein_design-2de03617-e4e6-4d54-9fdb-8
📅 Version Timeline
3 versions
v2
stability-opt
Introduced 3 stabilizing mutations from Rosetta energy minimization
v3
binding-opt
●
Interface mutations to enhance Aβ binding while maintaining stability gains
Version Details
v3
Current Version
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🌍 Provenance Graph
15 nodes, 57 edges
derives from (14)
hypothesis-h-044ee057→analysis-SDA-2026-04-01-gap-v2analysis-SDA-2026-04-01-gap-v2→hypothesis-h-044ee057hypothesis-h-b234254c→analysis-SDA-2026-04-02-gap-taanalysis-SDA-2026-04-02-gap-ta→hypothesis-h-b234254chypothesis-h-seaad-51323624→analysis-analysis-SEAAD-202604
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analysis-analysis-SEAAD-202604→hypothesis-h-seaad-51323624hypothesis-h-61196ade→analysis-SDA-2026-04-02-gap-aganalysis-SDA-2026-04-02-gap-ag→hypothesis-h-61196adehypothesis-h-180807e5→analysis-SDA-2026-04-01-gap-auanalysis-SDA-2026-04-01-gap-au→hypothesis-h-180807e5hypothesis-h-3460f820→analysis-SDA-2026-04-01-gap-91analysis-SDA-2026-04-01-gap-91→hypothesis-h-3460f820protein_design-2de03617-e4e6-4→protein_design-011c7116-97c0-4protein_design-2de03617-e4e6-4→protein_design-7a8f5722-d87e-4
Linked Artifacts (10)