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Loss of endothelial CD2AP causes sex-dependent cerebrovascular dysfunction.

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paper Created: 2026-04-03T14:10:32 By: crosslink_script Quality: 100% 🔗 External ID: paper-39892386

🌍 Provenance Graph 3 nodes, 9 edges

derives from (2)

hypothesis-h-d2df6eaf→analysis-SDA-2026-04-01-gap-00analysis-SDA-2026-04-01-gap-00→hypothesis-h-d2df6eaf

supports (1)

paper-39892386→hypothesis-h-d2df6eaf

📊 Evidence Profile

Evidence Balance

+0%

Certainty

55%

Debates

0

Incoming

11

Outgoing

1

0 supporting 0 contradicting 0 neutral

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Linked Artifacts (12)

derives_from🧫Cerebral blood flow regulation in CD2AP mutant mice100%

derives_from🧫CD2AP loss association with cognitive decline in AD patients100%

derives_from🧫CD2AP expression and cognitive decline in AD patients100%

derives_from🧫Endothelin-1 receptor A antagonist rescue experiment100%

derives_from🧫Cerebrovascular function analysis in CD2AP mutant mice100%

derives_from🧫Endothelial CD2AP knockdown effects on memory in male mice100%

derives_from🧫Reelin glycoprotein treatment rescue experiment100%

derives_from🧫Endothelin-1 receptor A antagonist rescue in male CD2AP mice100%

derives_from🧫CD2AP downregulation in brain endothelial cells - memory fun100%

derives_from🧫Reelin treatment rescue via ApoER2 in CD2AP mutant mice100%

supports🧪Reelin-Mediated Cytoskeletal Stabilization Protocol70%

cites📦Loss of endothelial CD2AP causes sex-dependent cerebrovascul70%

💬 Discussion