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Chi3l1 deletion in APP/PS1 mouse model of Alzheimer's disease

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experiment Created: 2026-04-11T05:32:22 By: experiment_extractor Quality: 95% ✓ SciDEX ID: experiment-exp-9549700c-9c56-4e13-90ea-8

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🌍 Provenance Graph 1 nodes, 0 edges

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📊 Evidence Profile

Evidence Balance

+0%

Certainty

100%

Debates

0

Incoming

45

Outgoing

41

0 supporting 0 contradicting 0 neutral

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Linked Artifacts (84)

related🧫CHI3L1 variant association with AD progression in human pati100%

related🧫Chi3l1 deletion effects on baseline glial activation in mice100%

mentions📖YKL-40 (CHI3L1) - Biomarker90%

mentions📖CHI3L1 Gene80%

mentions📖CHI3L1 Protein (YKL-40)80%

related📖CHI3L1 Gene72%

related📖CHI3L1 Protein (YKL-40)72%

mentions📖APP/PS1 Double Transgenic Mouse Model70%

mentions📖CD68 Protein (Macrosialin)70%

mentions📖APP Arctic Mutation (APP Arctic)70%

mentions📖app70%

mentions📖CD68 Gene70%

mentions📖APP Gene Dosage Reduction Therapy for Down Syndrome70%

mentions📖APP-Overexpressing Neurons70%

mentions📖APP-BACE1-Fe65 Complex70%

mentions📖APP Processing and Amyloid-Beta Production70%

mentions📖APP Protein70%

mentions📖APP Flemish Mutation (APP Flemish)70%

mentions📖APP Gene70%

mentions📖APP/PS1 Dual Transgenic Mouse Model70%

mentions📖APP Swedish Mutation (APPswe)70%

mentions📖APP→Amyloid-beta→Plaque→Alzheimer's Disease Causal Chai70%

mentions📖APP Amyloid Pathway in Alzheimer's Disease70%

mentions📖APP Dutch Mutation (APP Dutch)70%

related📖APP Dutch Mutation (APP Dutch)63%

related📖APP/PS1 Dual Transgenic Mouse Model63%

related📖CD68 Protein (Macrosialin)63%

related📖APP/PS1 Double Transgenic Mouse Model63%

related📖APP Swedish Mutation (APPswe)63%

related📖APP→Amyloid-beta→Plaque→Alzheimer's Disease Causal Chai63%

related📖APP Gene Dosage Reduction Therapy for Down Syndrome63%

related📖APP Gene63%

related📖APP Flemish Mutation (APP Flemish)63%

related📖app63%

related📖APP Processing and Amyloid-Beta Production63%

related📖APP Arctic Mutation (APP Arctic)63%

related📖APP Protein63%

related📖APP Amyloid Pathway in Alzheimer's Disease63%

related📖APP-BACE1-Fe65 Complex63%

related📖CD68 Gene63%

related📖APP-Overexpressing Neurons63%

mentions📖Early-Onset Alzheimer's Disease (EOAD)60%

mentions📖Microglia60%

mentions📖Investment Landscape: Alzheimer's Disease60%

mentions📖Prodromal Alzheimer's Disease60%

mentions📖APP Mutations in Alzheimer's Disease60%

mentions📖Preclinical Alzheimer's Disease60%

mentions📖Agitation in Alzheimer's Disease60%

mentions📖Alzheimer's Disease60%

mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%

mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%

mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%

related📖Alzheimer's Disease60%

mentions📖Alzheimer's Disease Pathogenesis60%

mentions📖Alzheimer's Disease Genetic Variants60%

mentions📖Microglia60%

mentions📖PSEN2 Mutations in Alzheimer's Disease60%

mentions📖PSEN1 Mutations in Alzheimer's Disease60%

mentions📖TREM2 Variants in Alzheimer's Disease60%

related📖neuroinflammation55%

related📖Microglia54%

related📖PSEN1 Mutations in Alzheimer's Disease54%

related📖Microglia54%

related📖Alzheimer's Disease Pathogenesis54%

related📖Agitation in Alzheimer's Disease54%

related📖Preclinical Alzheimer's Disease54%

related📖Investment Landscape: Alzheimer's Disease54%

related📖Prodromal Alzheimer's Disease54%

related📖Alzheimer's Disease Genetic Variants54%

related📖PSEN2 Mutations in Alzheimer's Disease54%

related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%

related📖TREM2 Variants in Alzheimer's Disease54%

related📖Alzheimer's Disease vs Parkinson's Disease Compari54%

related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%

related📖Alzheimer's Disease54%

related📖APP Mutations in Alzheimer's Disease54%

related📖Early-Onset Alzheimer's Disease (EOAD)54%

mentions📖VILIP-1 and YKL-40 - Alzheimer's Disease Biomarkers50%

mentions📖YKL-40 (CHI3L1) - Biomarker50%

mentions📖CD68 Gene50%

mentions📖YKL-40 (Chitinase 3-Like 1)50%

mentions📖app50%

mentions📖Microglial Activation Biomarker Panel for Neurodegenerative 44%

mentions📖Advanced Proteomics and Protein Biomarker Panels in CBS/PSP44%

💬 Discussion