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Sex differences in CB1R-mediated cannabinoid analgesia in neuropathic pain

active

experiment Created: 2026-04-11T07:49:09 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-8ad644d2-5765-4323-8c44-5

Related Entities

CNR1,CAMK2A,GAD2,SLC17A6

🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

📊 Evidence Profile

Evidence Balance

+0%

Certainty

100%

Debates

Incoming

188

Outgoing

0 supporting 0 contradicting 0 neutral

View full evidence profile →

Linked Artifacts (198)

mentions📖slc17a6 Protein80%

mentions📖Glutamate Decarboxylase 280%

mentions📖CaMKII Protein (CaMK2A)80%

mentions📖CNR1 Gene80%

mentions📖CNR1 Protein80%

mentions📖SLC17A6 Gene80%

mentions📖CAMK2A Gene80%

related📖CNR1 Protein72%

related📖SLC17A6 Gene72%

related📖slc17a6 Protein72%

related📖CAMK2A Gene72%

related📖Glutamate Decarboxylase 272%

related📖CNR1 Gene72%

related📖CaMKII Protein (CaMK2A)72%

mentions📖mechanisms60%

mentions📖researchers60%

mentions📖Medial Prefrontal Cortex60%

related📖researchers54%

related📖mechanisms54%

related📖Medial Prefrontal Cortex54%

mentions📖Horizontal Diagonal Band GABAergic Neurons50%

mentions📖Nucleus of the Brachium of the Inferior Colliculus50%

mentions📖Median Eminence Tanycytes50%

mentions📖Centromedian Thalamic Nucleus (CM) Neurons50%

mentions📖Parvalbumin Neurons (PV+)50%

mentions📖Endocannabinoid System Dysfunction Validation in Parkinson&#50%

mentions📖Cannabinoid CB1 Receptor Neurons50%

mentions📖Globus Pallidus External Segment GABA Neurons50%

mentions📖Nucleus of the Fields of Forel (FF) Neurons50%

mentions📖Pulvinar Neurons50%

mentions📖GABAergic Signaling Pathway in Neurodegeneration50%

mentions📖Nucleus of the Posterior Commissure50%

mentions📖Mediodorsal Thalamic Nucleus Neurons50%

mentions📖Central Amygdala Interneurons50%

mentions📖Cortical Ivy Cells50%

mentions📖Bistratified Interneurons50%

mentions📖Pedunculopontine Nucleus (PPN) Neurons - Expanded50%

mentions📖Cochlear Nuclei Neurons50%

mentions📖Cortical Layer 1 Neurons50%

mentions📖gabaergic-dysfunction50%

mentions📖Spinal Cord Propriospinal Neurons50%

mentions📖Tectospinal Projection Neurons50%

mentions📖Tufted Cells50%

mentions📖External Globus Pallidus (GPe) Neurons50%

mentions📖Reticular Formation Neurons50%

mentions📖Preoptic Area GABAergic Neurons50%

mentions📖Sagulum Nucleus (Nucleus Sagulum) Neurons50%

mentions📖GABAergic Neurons50%

mentions📖LAMP5+ Interneurons50%

mentions📖Red Nucleus Neurons50%

mentions📖Preoptic Area Neurons50%

mentions📖Internal Globus Pallidus (GPi) Neurons50%

mentions📖Globus Pallidus externa (GPe) Neurons50%

mentions📖Nucleus of the Solitary Tract (NTS) Neurons50%

mentions📖Medial Habenula Neurons50%

mentions📖Kolliker-Fuse Nucleus (KFn) Neurons50%

mentions📖Substantia Nigra Pars Reticulata (SNr) Neurons50%

mentions📖Glutamate Decarboxylase (GAD) Neurons50%

mentions📖Thalamic Reticular Nucleus (TRN) Neurons50%

mentions📖Globus Pallidus Neurons50%

mentions📖Zona Incerta (ZI) Neurons50%

mentions📖Nucleus Limitans Neurons50%

mentions📖Median Raphe Neurons50%

mentions📖Martinotti Cells50%

mentions📖Thalamic Ventrobasal Neurons50%

mentions📖Substantia Nigra pars Reticulata (SNr) GABA Neurons50%

mentions📖Basket Cells (Fast-Spiking PV+)50%

mentions📖Inferior Colliculus Core50%

mentions📖Interstitial Nucleus of the Medial Longitudinal Fasciculus50%

mentions📖Paraventricular Thalamic Nucleus (PVT) Neurons50%

mentions📖Bötzinger Complex Neurons50%

mentions📖Lateral Septal Neurons50%

mentions📖Nucleus Paragigantocellularis Lateralis Neurons50%

mentions📖Calretinin (CR+) Interneurons50%

mentions📖Ventral Posterolateral Thalamic Nucleus (VPL) Neurons50%

mentions📖Lateral Habenula Neurons50%

mentions📖Hippocampal HIPP Interneurons50%

mentions📖Globus Pallidus interna (GPi) Neurons50%

mentions📖Pretectal Olivary Neurons50%

mentions📖Reticularis Pontis Oralis Neurons50%

mentions📖CBS Single-Cell Transcriptomics Mechanisms50%

mentions📖Spinal Vestibular Nucleus (SpVN) Neurons50%

mentions📖Endocannabinoid System Dysfunction Hypothesis in Parkinson&#50%

mentions📖Solitary Nucleus Neurons50%

mentions📖Lateral Reticular Nucleus Neurons50%

mentions📖Axo-Axonic Cells (Chandelier Cells)50%

mentions📖Medial Vestibular Nucleus Neurons50%

mentions📖Lateral Habenula Neurons50%

mentions📖Parvicellular Reticular Formation Neurons50%

mentions📖Anterior Olfactory Nucleus (AON) Neurons50%

mentions📖PPN GABAergic Neurons50%

mentions📖Rostral Interstitial Nucleus of MLF Neurons44%

mentions📖Gigantocellular Nucleus (Gi) Neurons44%

mentions📖GABAergic Signaling Dysfunction in Neurodegeneration44%

mentions📖Dorsal Raphé Nucleus Serotonergic Neurons44%

mentions📖Median Raphe Nucleus (MRN) Neurons44%

mentions📖Ventral Posterior Thalamic Nucleus (VPL/VPM) Neurons44%

mentions📖Substantia Nigra Pars Reticulata GABA Output Neurons44%

mentions📖Spinal Dorsal Horn Neurons44%

mentions📖Precommissural Nucleus (PrC) Neurons44%

mentions📖Raphe Pallidus (RPa) Neurons44%

mentions📖Retinal Ganglion Cells (RGCs)44%

mentions📖Cerebellar Golgi Cells44%

mentions📖Ventral Pallidum Neurons44%

mentions📖Lateral Hypothalamic Orexin Neurons44%

mentions📖Pretectal Nucleus Neurons44%

mentions📖Parabrachial Neurons44%

mentions📖Hippocampal CA1 Interneurons44%

mentions📖Substantia Nigra Pars Reticulata (SNr) Expanded44%

mentions📖Arcuate Nucleus of Medulla44%

mentions📖Subthalamic Nucleus (STN) Neurons44%

mentions📖Substantia Nigra Pars Reticulata44%

mentions📖Posterior Thalamic Nucleus (VPL/VPM) Neurons44%

mentions📖GABAergic Neurons in Neurodegeneration44%

mentions📖Pontine Reticular Nucleus (Oral Part)44%

mentions📖Pterygopalatine Ganglion (PPG) Neurons44%

mentions📖Nucleus Ruber (Red Nucleus) Neurons44%

mentions📖Substantia Nigra Pars Reticulata Neurons44%

mentions📖Subthalamic Nucleus Glutamatergic Neurons44%

mentions📖Medial Septum GABAergic Neurons44%

mentions📖Anterior Thalamic Nucleus (ATN) Neurons44%

mentions📖Synaptic Vesicle Cycle44%

mentions📖Nucleus Cuneatus Neurons44%

mentions📖Raphe Magnus Pain Modulation Neurons44%

mentions📖Perifornical Nucleus (PeF) Neurons44%

mentions📖Rubrospinal Neurons44%

mentions📖Reticulospinal Neurons44%

mentions📖Terminal Nucleus Neurons44%

mentions📖Nucleus of the Optic Tract (NOT) Neurons44%

mentions📖Deep Mesencephalic Nucleus (DpMe) Neurons44%

mentions📖Interstitial Nucleus of the Vestibulospinal Tract (INV) Neur44%

mentions📖Raphe Obscurus (ROb) Neurons44%

mentions📖Lateral Hypothalamic Area (LHA) Neurons44%

mentions📖Insular Cortex Neurons44%

mentions📖Retroambiguus Nucleus (RA) Neurons44%

mentions📖Ventral Tegmental Area Glutamatergic Neurons44%

mentions📖Double Bouquet Cells44%

mentions📖Basolateral Amygdala (BLA) Neurons44%

mentions📖Oral Trigeminal Nucleus (Vo) Neurons44%

mentions📖Kölliker-Fuse Nucleus Neurons44%

mentions📖Medial Amygdala (MeA) Neurons44%

mentions📖Medial Terminal Nucleus Neurons44%

mentions📖Spinocerebellar Neurons44%

mentions📖Parastrial Nucleus (PS) Neurons44%

mentions📖Paraventricular Nucleus of Thalamus44%

mentions📖Spinal Vestibular Nucleus (SpVN) Expanded44%

mentions📖Retrotrapezoid Nucleus (RTN) Neurons44%

mentions📖Rhomboid Thalamic Nucleus44%

mentions📖Parasubthalamic Nucleus (PSTN) Neurons44%

mentions📖Cortical Interneurons44%

mentions📖Red Nucleus Neurons44%

mentions📖Spinal Trigeminal Nucleus Caudalis44%

mentions📖Nodose Ganglion Neurons44%

mentions📖Vestibular Nucleus Neurons44%

mentions📖Spinal Interneurons44%

mentions📖Barrington's Nucleus (Pontine Micturition Center) Neuro44%

mentions📖Neurogliaform Cells44%

mentions📖Interpeduncular Nucleus (IPN) Neurons44%

mentions📖Endocannabinoid System in Neurodegeneration44%

mentions📖VIP-Positive Cortical Interneurons44%

mentions📖Rostral Ventral Respiratory Group (rVRG) Neurons44%

mentions📖Striatal Fast-Spiking Interneurons44%

mentions📖Pre-Bötzinger Complex Expanded v244%

mentions📖Posterodorsal Tegmental Nucleus (PDTg) Neurons44%

mentions📖Vestibular Nuclei Complex (Expanded)44%

mentions📖Paraventricular Nucleus (PVN) CRH Neurons44%

mentions📖Inferior Colliculus Neurons44%

mentions📖Bed Nucleus of Stria Terminalis in Stress44%

mentions📖Reuniens Thalamic Nucleus44%

mentions📖Vestibular Nuclei Neurons44%

mentions📖Periolivary Nucleus44%

mentions📖Deep Layer Superior Colliculus (dlSC) Neurons44%

mentions📖Vesicular Glutamate Transporter (VGLUT) Neurons44%

mentions📖Septal GABAergic Neurons44%

mentions📖Supramammillary Nucleus (SuM) Neurons44%

mentions📖Ventral Tegmental Area Dopaminergic Neurons44%

mentions📖Cholecystokinin-Expressing Interneurons (CCK Interneurons)44%

mentions📖Reticular Formation Neurons44%

mentions📖Nucleus of the Lateral Lemniscus (LLL) Neurons44%

mentions📖Periaqueductal Gray Neurons44%

mentions📖Spinal Vestibular Nucleus Neurons44%

mentions📖Endopiriform Neurons44%

mentions📖Lateral Geniculate Nucleus (LGN) Neurons44%

mentions📖Medial Accessory Olive Neurons44%

mentions📖Sublaterodorsal Nucleus (SLD) Neurons44%

mentions📖Superior Temporal Gyrus Neurons44%

mentions📖Neuroregeneration Therapies for Neurodegeneration44%

mentions📖Postinspiratory Complex Neurons44%

mentions📖iPSC-Derived GABAergic Neurons44%

mentions📖Midline Thalamic Nuclei44%

mentions📖Pre-Bötzinger Complex Neurons44%

mentions📖Subthalamic Nucleus Glutamate Neurons44%

mentions📖Spinal Trigeminal Nucleus (Sp5) Neurons44%

mentions📖Habenular Nuclei44%

mentions📖Paramedian Pontine Reticular Formation (PPRF) Neurons44%

mentions📖Ventral Lateral Thalamic Nucleus (VL) Neurons44%

Sex differences in CB1R-mediated cannabinoid analgesia in neuropathic pain

💬 Discussion