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P2RY12-MTOR pathway interaction in VSMCs

experiment Created: 2026-04-04T12:26:15 By: experiment_extractor Quality: 85% ✓ SciDEX ID: experiment-exp-764173ae-f63f-452f-b821-2

Related Entities

P2RY12, MTOR

🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

experiment-exp-764173ae-f63f-4→paper-32160082

📊 Evidence Profile

Evidence Balance

+0%

Certainty

100%

Debates

Incoming

125

Outgoing

0 supporting 0 contradicting 0 neutral

View full evidence profile →

Linked Artifacts (152)

experiment_target📖P2RY12100%

mentions📖MTOR100%

derives_from📄The P2RY12 receptor promotes VSMC-derived foam cell formatio100%

mentions📖P2RY12100%

mentions📖MTOR Protein80%

related📖MTOR Protein72%

mentions📖PI3K — Phosphoinositide 3-Kinase70%

mentions📖MTOR Gene70%

mentions📖P2RY12 Gene70%

mentions📖PI3K p110α Protein70%

mentions📖pi3k-akt-signaling70%

mentions📖AKT (Protein Kinase B) Neurons70%

mentions📖PI3K/Akt Signaling in Neurodegeneration70%

mentions📖PI3K/AKT/mTOR Signaling Pathway in Neurodegeneration70%

mentions📖PI3K-Akt Signaling in Parkinson's Disease70%

mentions📖PI3K/Akt Signaling in Parkinson's Disease70%

mentions📖MTOR (Redirect)70%

mentions📖MTOR Gene70%

mentions📖mtor-inhibitor-therapy-parkinsons70%

mentions📖PI3K/Akt Activator Clinical Trials for Parkinson's Dise70%

mentions📖akt-protein70%

mentions📖PI3K Protein70%

related📖AKT (Protein Kinase B) Neurons63%

related📖MTOR Gene63%

related📖akt-protein63%

related📖PI3K Protein63%

related📖MTOR (Redirect)63%

related📖MTOR Gene63%

related📖P2RY12 Gene63%

related📖PI3K p110α Protein63%

related📖pi3k-akt-signaling63%

mentions📖researchers60%

mentions📖Autophagy60%

mentions📖autophagy60%

related📖researchers54%

related📖Autophagy54%

related📖autophagy54%

mentions📖AMPK Agonist Therapy for Neurodegeneration50%

mentions📖VTA GABAergic Neurons50%

mentions📖Ventral Pallidum in Reward Valuation50%

mentions📖Ventrolateral Preoptic GABAergic Neurons50%

mentions📖Globus Pallidus External Segment Neurons50%

mentions📖GABA Receptors in Neuronal Inhibition50%

mentions📖Flocculus Neurons50%

mentions📖Pars Reticularis Nigral Neurons50%

mentions📖Horizontal Limb of the Diagonal Band (HDB)50%

mentions📖Dentate Gyrus Granule Cells in Temporal Lobe Epilepsy50%

mentions📖Purkinje Cell Axonal Terminals50%

mentions📖Insulin and IGF Signaling in 4R-Tauopathies50%

mentions📖Renshaw Cells in Recurrent Inhibition50%

mentions📖Laterodorsal Tegmental Nucleus GABAergic Neurons50%

mentions📖Golgi Cells50%

mentions📖Horizontal Limb of the Diagonal Band (HDB)50%

mentions📖Cerebellar Purkinje Cells in Motor Coordination50%

mentions📖Triangular Nucleus of the Septum (Tria) Neurons50%

mentions📖Protein Synthesis in Neurodegenerative Diseases50%

mentions📖Reticularis Pontis Oralis Neurons50%

mentions📖Peroxisome Dysfunction in Neurodegeneration50%

mentions📖Habenula Neurons in Mood and Reward50%

mentions📖Tumor Necrosis Factor (TNF)50%

mentions📖PV Interneurons (Hippocampus)50%

mentions📖Disease Classification & Relationships50%

mentions📖Median Preoptic Nucleus in Sleep Pressure50%

mentions📖Globus Pallidus Internal Segment (GPi) GABAergic Neurons50%

mentions📖Pre-Botzinger Complex in Respiratory Rhythm50%

mentions📖Ventral Pallidum Neurons in Motivation50%

mentions📖Dentate Gyrus Neurons in Temporal Lobe Epilepsy50%

mentions📖Habenula in Reward Prediction50%

mentions📖Autism Spectrum Disorder50%

mentions📖Ventrolateral Preoptic Area (VLPO) Neurons50%

mentions📖Parvalbumin Expressing Interneurons50%

mentions📖HIF Therapeutics for Neurodegeneration — Investment Landscap50%

mentions📖Aging to AD Switch: Triggers50%

mentions📖Habcnular Commissure Fibers50%

mentions📖Tuberomammillary Nucleus Expanded50%

mentions📖Epilepsy50%

mentions📖Baclofen50%

mentions📖Cortical Chandelier Cells50%

mentions📖Main Olfactory Bulb (MOB) Neurons50%

mentions📖Medial Septal Cholinergic Neurons50%

mentions📖Ventral Pallidum (VP) Neurons50%

mentions📖Median Raphe Nucleus50%

mentions📖MAPK/ERK Signaling Pathway in Neurodegeneration50%

mentions📖GABA-C Receptor Neurons50%

mentions📖Horizontal Cells of the Striatum50%

mentions📖GABAergic Neuron Vulnerability50%

mentions📖Retinal Horizontal Cells50%

mentions📖Dentate Gyrus Granule Cells in Temporal Lobe Epilepsy50%

mentions📖Spinal Cord Lamina X Neurons50%

mentions📖P2RY12 Gene50%

mentions📖GSK3 Inhibitor Therapy50%

mentions📖Cortical Bipolar GABAergic Interneurons50%

mentions📖Olfactory Bulb Short-Axon Cells50%

mentions📖Intercalated Amygdala Nucleus Neurons50%

mentions📖Medial Geniculate Body50%

mentions📖Inferior Colliculus in Sound Localization50%

mentions📖Globus Pallidus Internus (GPi) Neurons50%

mentions📖Autophagy-Lysosomal Pathway50%

mentions📖Reticular Thalamic Nucleus GABAergic Neurons50%

mentions📖Lateral Lemniscus Neurons50%

mentions📖Cochlear Nuclei in Auditory Processing50%

mentions📖Lateral Preoptic Area Neurons50%

mentions📖Tuberomammillary Nucleus Histaminergic Neurons50%

mentions📖GABA Transporter (GAT) Neurons50%

mentions📖Thalamic Reticular Nucleus in Epilepsy50%

mentions📖Kölliker-Fuse Subnucleus50%

mentions📖mTOR Signaling in Autophagy and Lysosomal Function50%

mentions📖Hippocampal CA3 Pyramidal Neurons in Epilepsy50%

mentions📖Axo-Axonic Cells50%

mentions📖Dentate Gyrus Granule Cells in Temporal Lobe Epilepsy50%

mentions📖Cerebellar Stellate Cells50%

mentions📖Preoptic Area Sleep-Active Neurons50%

mentions📖Ventral Tegmental Area GABAergic Neurons50%

mentions📖Laterodorsal Tegmental Nucleus50%

mentions📖Wernickes Area50%

mentions📖MTOR Gene50%

mentions📖Interstitial Nucleus of Cajal50%

mentions📖Laterodorsal Tegmental Nucleus50%

mentions📖Preoptic Area GABAergic Neurons50%

mentions📖Lateral Pericentral Nucleus of Inferior Colliculus Neurons50%

mentions📖Spinal Lamina II Neurons50%

mentions📖Anterior Hypothalamic Area Neurons50%

mentions📖Striatal Parvalbumin Interneurons50%

mentions📖AMPK (AMP-Activated Protein Kinase)50%

mentions📖Dorsal Raphe Nucleus50%

mentions📖Cortical Basket Cells (Parvalbumin-Positive)50%

mentions📖Interpeduncular Nucleus in Nicotine50%

mentions📖Globus Pallidus Externus (GPe) Neurons50%

mentions📖Ceftriaxone for Amyotrophic Lateral Sclerosis44%

mentions📖rock-inhibitor-therapy-parkinsons44%

mentions📖Retinitis Pigmentosa44%

mentions📖Growth Factor Therapies for Neurodegeneration44%

mentions📖Sodium Oligomannate (GV-971) for Alzheimer's Disease44%

mentions📖Autophagy-Lysosomal Impairment Across Neurodegenerative Dise44%

mentions📖sglt2-inhibitors-neurodegeneration44%

mentions📖MPAN — Mitochondrial Membrane Protein-Associated Neurodegene44%

mentions📖Growth Factor Therapies44%

mentions📖Neural Precursor Development44%

mentions📖Autophagy Types in Neurodegeneration44%

mentions📖Metabolic Dysfunction in 4R-Tauopathies44%

mentions📖Growth Factor Therapeutics: Investment Landscape Analysis44%

mentions📖cell-proliferation44%

P2RY12-MTOR pathway interaction in VSMCs

derives from (1)

💬 Discussion