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Molecular docking analysis of aminophylline binding targets

active

experiment Created: 2026-04-11T05:36:02 By: experiment_extractor Quality: 80% ✓ SciDEX ID: experiment-exp-62a12833-386d-46c4-b201-6

Related Entities

PDE3, PDE4, SERT

🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

📊 Evidence Profile

Evidence Balance

+0%

Certainty

100%

Debates

0

Incoming

93

Outgoing

4

0 supporting 0 contradicting 0 neutral

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Linked Artifacts (96)

mentions📖PDE4 Inhibitor PD Trial80%

related📖PDE4 Inhibitor PD Trial72%

related📖depression70%

mentions📖mechanisms60%

mentions📖Depression (Major Depressive Disorder)60%

related📖Depression (Major Depressive Disorder)60%

related📖mechanisms54%

related📖Depression (Major Depressive Disorder)54%

mentions📖Serotonin (5-Hydroxytryptamine, 5-HT)50%

mentions📖Dorsal Raphe Nucleus50%

mentions📖Dorsal Raphe in Parkinson's Disease50%

mentions📖Phosphodiesterase (PDE) Inhibitors for Neurodegeneration50%

mentions📖Linear Raphe Nucleus50%

mentions📖Ibudilast50%

mentions📖Serotonergic Neurons50%

mentions📖Serotonin (5-HT) Receptor Modulators for Neurodegeneration50%

mentions📖SSRI Antidepressants50%

mentions📖Pontine Raphe Nucleus Serotonergic50%

mentions📖Serotonin Signaling Pathway50%

mentions📖Serotonergic Raphe Neurons in Depression and Neurodegenerati50%

mentions📖cAMP Signaling Pathway in Neurodegeneration50%

mentions📖Serotonergic Dysfunction in Neurodegeneration50%

mentions📖Linear Nucleus of the Raphe (R Li) Neurons50%

mentions📖VMAT2 - Dopaminergic Biomarker50%

mentions📖Serotonin Neurons50%

mentions📖Serotonergic Raphe Neurons in Migraine50%

mentions📖Median Raphe Nucleus50%

mentions📖Serotonin Spinal Projection Neurons50%

mentions📖Pontine Raphe in Serotonergic Modulation50%

mentions📖Nucleus Raphe Obscurus50%

mentions📖Serotonin Transporter (SERT) Neurons50%

mentions📖Citalopram Depression AD Trial50%

mentions📖Trace Amine-Associated Receptor (TAAR) Neurons50%

mentions📖Serotonergic System in Neurodegeneration50%

mentions📖Section 205: Advanced Myelin and White Matter Therapy in CBS50%

mentions📖Serotonin Transporter (SERT) Neurons50%

mentions📖Tryptophan Hydroxylase (TPH) Neurons50%

mentions📖Phosphodiesterase Inhibitors for Parkinson's Disease50%

mentions📖Dorsal Raphe Nucleus Serotonergic50%

mentions📖Non-Dopaminergic Neurotransmitter Degeneration as Upstream D50%

mentions📖cAMP Signaling in Neurodegeneration50%

mentions📖Serotonergic Dorsal Raphe Nucleus Neurons50%

mentions📖Serotonergic Neurons (Raphe Nuclei)50%

mentions📖Nucleus Raphes Magnus Expanded (NRM)50%

mentions📖Raphe Nucleus Serotonergic Neurons in Parkinson's Disea50%

mentions📖Dorsal Raphe Nucleus (DRN) Serotonin Neurons50%

mentions📖Enterochromaffin Cells50%

mentions📖serotonergic-raphe-neurons50%

mentions📖raphe-nuclei-serotonin50%

mentions📖psp-serotonergic-dysfunction50%

mentions📖Pontine Raphe Nucleus (PRn) Neurons44%

mentions📖Raphe Serotonergic Neurons in Depression and Neurodegenerati44%

mentions📖Raphe Pallidus (RPa) Neurons44%

mentions📖serotonin-5-ht1b-receptor-neurons44%

mentions📖Serotonin 5-HT3 Receptor Neurons44%

mentions📖Dorsal Raphe Serotonin in Depression44%

mentions📖Gene-Mechanism-Therapy Causal Chains44%

mentions📖Serotonin 5-HT1D Receptor Neurons44%

mentions📖Nucleus Raphe Magnus Serotonergic Neurons44%

mentions📖Neurotransmitter System Changes in 4R-Tauopathies: Cross-Dis44%

mentions📖Nucleus Raphe Magnus44%

mentions📖Dorsal Raphe Serotonergic Neurons (Expanded)44%

mentions📖Brainstem Serotonergic Neurons44%

mentions📖CHCHD10 Mitochondrial Dysfunction — ALS/FTD Causal Chain44%

mentions📖Raphe Pallidus Neurons44%

mentions📖Median Raphe Serotonergic Neurons44%

mentions📖Dorsal Raphe Nucleus (DRN) Expanded44%

mentions📖Serotonin Neurons in Mood Regulation44%

mentions📖PI3K/Akt Activator Clinical Trials for Parkinson's Dise44%

mentions📖Brainstem Serotonergic Neurons in Parkinson Disease44%

mentions📖Oligodendrocytes44%

mentions📖Serotonin 5-HT1A Receptor Neurons44%

mentions📖Neuroregeneration Therapies for Neurodegeneration44%

mentions📖Serotonin 5-HT2A Receptor Neurons44%

mentions📖serotonin-5-ht1e-receptor-neurons44%

mentions📖serotonin-5-ht1f-receptor-neurons44%

mentions📖Dorsal Raphe Serotonergic Neurons in Parkinson's Diseas44%

mentions📖Dorsal Raphe Serotonergic Projection Neurons44%

mentions📖Median Raphe Serotonergic Neurons44%

mentions📖adenylyl-cyclase-neurons44%

mentions📖Dorsal Raphe Nucleus44%

mentions📖Raphespinal Neurons44%

mentions📖Dorsal Raphe Nucleus Serotonergic Projection Neurons44%

mentions📖Serotonin 5-HT2C Receptor Neurons44%

mentions📖Amyotrophic Lateral Sclerosis (ALS) Treatment44%

mentions📖Median Raphe Serotonergic Neurons44%

mentions📖Escitalopram for Agitation in Alzheimer's Disease (NCT044%

mentions📖Vesicular Monoamine Transporter 2 (VMAT2) Pathway in Parkins44%

mentions📖Median Raphe Nucleus (MRN) Neurons44%

mentions📖Nucleus Raphé Pallidus Serotonergic Neurons44%

mentions📖iPSC-Derived Serotonergic Neurons44%

mentions📖Raphe Magnus Pain Modulation Neurons in Neurodegeneration44%

mentions📖Dorsal Raphe Nucleus Serotonin Neurons (Expanded)44%

mentions📖Serotonin 5-HT1A Receptor Neurons44%

mentions📖Dorsal Raphé Nucleus Serotonergic Neurons44%

mentions📖Linear Nucleus of Raphe Neurons44%

💬 Discussion