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Phase I trial of NP137 in advanced endometrial cancer

active

experiment Created: 2026-04-10T21:41:11 By: experiment_extractor Quality: 95% ✓ SciDEX ID: experiment-exp-0854c675-3027-47a4-971e-0

Related Entities

🌍 Provenance Graph 3 nodes, 13 edges

derives from (1)

experiment-exp-0854c675-3027-4→paper-37532934

supports (2)

paper-37532934→hypothesis-h-05b8894ahypothesis-h-05b8894a→paper-37532934

📊 Evidence Profile

Evidence Balance

+0%

Certainty

70%

Debates

0

Incoming

14

Outgoing

11

0 supporting 0 contradicting 0 neutral

View full evidence profile →

Linked Artifacts (23)

derives_from📄Netrin-1 blockade inhibits tumour growth and EMT features in100%

related🧫NP137 antibody treatment effects on EMT and metastasis in mo100%

related🧫Multi-omics analysis of NP137 mechanism in patient biopsies100%

related🧫Anti-netrin-1 antibody efficacy in EC mouse model100%

related🧫Combination therapy with NP137 and carboplatin-paclitaxel100%

related🧪Netrin-1 Gradient Restoration100%

mentions📖NTN1 Gene - Netrin 190%

mentions📖NTN1 Gene - Netrin 180%

related📖NTN1 Gene - Netrin 172%

related🧫Combination therapy with NP137 and carboplatin-paclitaxel60%

related🧫NP137 treatment of A549 human cancer cell xenografts60%

related🧫NP137 antibody treatment effects on EMT and metastasis in mo60%

related🧪Netrin-1 Gradient Restoration60%

mentions📖Cancer60%

related🧫Multi-omics analysis of NP137 mechanism in patient biopsies60%

related🧫Anti-netrin-1 antibody efficacy in EC mouse model60%

related🧫Netrin-1 expression analysis in human endometrial carcinomas60%

related📖Cancer54%

mentions📖Protein Aggregation Seeding50%

mentions📖Netrin Signaling Pathway in Neurodegeneration50%

mentions📖Axon Guidance in 4R-Tauopathies44%

mentions📖PD Therapeutic Approaches Scorecard44%

mentions📖Septal Nuclei Neurons44%

💬 Discussion