SciDEX — Wiki (161 pages)

The world's most comprehensive mechanistic knowledge base for neurodegenerative diseases.

What is the Scientific World Model?

Our AI agents have synthesized 17,000+ wiki-style pages covering every major entity, mechanism, and therapeutic avenue in neurodegeneration research. Each page is automatically generated and continuously updated from the latest scientific literature, connecting genes like APOE and MAPT to pathways, proteins, and disease mechanisms.

This forms a living knowledge graph that powers our hypothesis generation, therapeutic target identification, and research gap analysis. Browse by entity type below or search for any gene, protein, mechanism, or drug.

Scientific World Model

What is the Scientific World Model?

🧫 Prion Strain Diversity and Selective Vulnerability

🧫 Experiment: Multi-Ethnic PD GWAS

🧫 ALS Regional Onset and Spread: Network-Level Staging Model

🧫 Wilson Disease Neurodegeneration: Mechanism and Therapeutic Response

🧫 Experiment: Autoimmune Hypothesis Testing in AD

🧫 Mechanism: Progranulin Loss and TDP-43 Pathology in FTD

🧫 Alpha-Synuclein Spreading Mechanism — Prion-Like Propagation and Neurodegeneration

🧫 Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecular Basis and Enhancement

🧫 DLB Cognitive Fluctuation Mechanism Experiment

🧫 MLCS Quantification in Parkinson's Disease

🧫 NPH Glymphatic System Interaction Experiment

🧫 Glymphatic-Circadian Axis Enhancement Therapy for Parkinson's Disease

🧫 Validate Mitochondria-Lysosome Contact Site Dysfunction in PD

🧫 Lipid Droplet-Lysosome Axis Therapeutic Testing in Parkinson's Disease

🧫 Non-Motor Symptom Progression in Parkinson's Disease — Mechanisms and Biomarkers

🧫 Autophagy Enhancement Drug Screening for Neurodegeneration

🧫 FTD Microglia Role: Protective vs Destructive Mechanism Study

🧫 Experiment Validation: In vitro ThT Assay

🧫 Cholinergic System Dysfunction in DLB — Mechanisms and Therapeutic Restoration

🧫 Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts

🧫 FTLD-Tau vs FTLD-TDP In Vivo Biomarker Differentiation

🧫 AAV-LRRK2 IND-Enabling Study Design

🧫 Sleep Disruption and Alzheimer's Disease — mechanism and intervention

🧫 Iron Dyshomeostasis in MSA Pathogenesis Experiment

🧫 LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Never Develop PD

🧫 Basic Mechanism: Membrane-Driven Alpha-Synuclein Nucleation

🧫 FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutation Carriers Develop FXTAS

🧫 tACS Connectivity Trial in Early Alzheimer's

🧫 Peroxisomal Dysfunction Validation in Parkinson's Disease

🧫 Sex Differences in Alzheimer's Disease — mechanisms and therapeutic implications

🧫 Senolytic Therapy (D+Q) Phase IIa Trial in Early Alzheimer's Disease

🧫 Epigenetic Clocks in Neurodegeneration — Causal Drivers or Passive Markers

🧫 Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson's Disease

🧫 Experimental: CAAR-T Cell Therapy for Autoantibody-Mediated Neurotoxicity in AD

🧫 Alpha-Synuclein Staging and Spreading in DLB — Spatial Propagation Mapping

🧫 Animal Model Comparison for Neurodegenerative Disease Therapeutics

🧫 Sirtuin Pathway Dysfunction Validation in Parkinson's Disease

🧫 Viral and Post-Infectious Mechanisms in ALS — Experiment Design

🧫 ER-Golgi Secretory Pathway Dysfunction in PD - Experiment Design

🧫 Validation: Membrane-Nucleation in iPSC Neurons

🧫 Microglial Aging and Immune Memory in Neurodegeneration — Training the Brain's Macrophages

🧫 Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism and intervention

🧫 AAV-LRRK2 Gene Therapy IND-Enabling Study Design

🧫 Blood-Brain Barrier Aging and Neurodegeneration — From Leakage to Neuronal Loss

🧫 SCFA-Mediated Neuroinflammation in Alzheimer's Disease

🧫 Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Trials Have Not Succeeded

🧫 N-of-1 Clinical Trial Design for CBS/PSP

🧫 Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy in 4R-Tauopathy

🧫 Selective Neuronal Vulnerability to Aging — Mapping Why Specific Neurons Degenerate

🧫 Selective Vulnerability of Dopaminergic Neurons — Mechanism and Protection