| Gene Symbol | ent-gene-28e2cb01 |
| Phagocytosis | TREM2 activation enhances microglial clearance of pathological protein aggregates and cellular debris |
| Metabolic reprogramming | TREM2 signaling supports the inflammatory metabolic state of disease-associated microglia (DAM) |
| Survival signaling | TREM2 provides pro-survival signals that prevent microglial apoptosis |
| Clustering | TREM2 promotes microglial clustering around pathological lesions, forming a protective barrier |
| Mechanism | Agonist antibody binding to extracellular domain of TREM2 |
| Company | Alector (developed with AbbVie) |
| Phase | Phase 2 (INVOKE-2 trial) |
| Indications | Alzheimer's disease |
| KG Connections | 94 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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