Contents

RIPK1 Inhibitors for Neurodegeneration

🔬 Protein Info

Gene Symbol	ent-gene-a08ba4ea
Mechanism	Selectively inhibits RIPK1 autophosphorylation at Ser166
ALS	Protected motor neurons in SOD1G93A mouse model through inhibition of TNF-α-mediated necroptosis
AD	Reduced hippocampal neuronal loss and improved cognitive function in 5xFAD mice
PD	Preserved dopaminergic neurons in MPTP mouse model
KG Connections	2 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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