| Gene Symbol | ent-gene-679b721f |
| Mendelian mutations | GPR37 loss-of-function mutations cause autosomal recessive juvenile parkinsonism with features resembling PARK2 (PARKIN) mutations |
| Association with sporadic PD | GPR37 polymorphisms are associated with altered PD risk in genome-wide association studies[@liu2021] |
| Co-localization with PARKIN | GPR37 physically interacts with PARKIN, the E3 ubiquitin ligase mutated in the second most common form of familial PD |
| Orphan receptor | Despite structural similarity to endothelin receptors, no definitive endogenous ligand has been established |
| Constitutively active | Exhibits baseline signaling activity independent of ligand |
| G protein coupling | Primarily Gi/Go-coupled, inhibiting adenylate cyclase |
| β-arrestin pathway | Signals through β-arrestin-dependent mechanisms independent of G proteins |
| ER retention | Mutant GPR37 is retained in the ER, causing cellular stress |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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