| Gene Symbol | ent-gene-8c4c3123 |
| PI3K/Akt pathway | Promotes neuronal survival and growth[@kaplan2000] |
| MAPK/ERK pathway | Regulates synaptic plasticity and dendritic growth[@sweatt2001] |
| PLCγ pathway | Modulates calcium signaling and neurotransmitter release[@minichiello2009] |
| Alzheimer's disease | Decreased BDNF in hippocampus and cortex correlates with cognitive decline[@peng2005] |
| Parkinson's disease | Reduced BDNF in substantia nigra contributes to dopaminergic neuron vulnerability[@mogi1999] |
| Huntington's disease | BDNF transport from cortex to striatum is impaired, leading to striatal atrophy[@baquet2004] |
| Depression | Low BDNF is associated with treatment-resistant depression in some studies[@castrn2010] |
| Selegiline | MAO-B inhibitor increases BDNF expression in vitro and in vivo[@tatton2002] |
| Memantine | NMDA antagonist upregulates BDNF in some studies[@huang2005] |
| SSRIs | Chronic antidepressant treatment increases BDNF expression[@duman2006] |
| AMPAkines | Positive allosteric modulators of AMPA receptors enhance BDNF release[@lauterborn2000] |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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