| Gene Symbol | SLC6A5 |
| Aliases | Glycine Transporter 1 |
| Chromosome | 11p15.5 |
| Protein Type | Receptor |
| Function | encodes a 12-transmembrane-domain protein of approximately 635 amino acids. |
| Primary Expression | astrocytes and endothelial cells of the blood-brain barrier |
| Amino Acids | 635 aa |
| GeneCards | SLC6A5 |
| Human Protein Atlas | SLC6A5 |
| N-terminal intracellular domain | Contains regulatory motifs for protein kinase C (PKC) phosphorylation and interaction with scaffolding proteins. |
| Transmembrane core | Forms the substrate-binding pocket (S1 site) and the gated external vestibule. The transporter alternates between outward-facing and inward-facing conformations during the transport cycle. |
| Extracellular loops | Highly glycosylated, with N-linked glycosylation sites essential for proper folding and surface expression. |
| C-terminal intracellular tail | Contains a PDZ-binding motif for interaction with synaptic scaffolding proteins and determines subcellular localization. |
| Glycinergic tone | Steady-state glycine concentrations at glycine receptors |
| NMDA receptor modulation | Glycine is a co-agonist at NMDA-type glutamate receptors; GlyT1 indirectly regulates glutamatergic excitotoxicity through glycine availability |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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