| Gene Symbol | TYRO3PROTEIN |
| Full Name | Tyro3 |
| Protein Type | Protein |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the central nervous system, particularly in neurons, microglia, and [astrocytes](/enti |
| Subcellular Localization | ** Cell membrane, Endosomes **Protein Family:** TAM Receptor Tyrosine Kinase Fam |
| Molecular Weight | 140 kDa |
| UniProt ID | Search UniProt |
| GeneCards | TYRO3PROTEIN |
| Human Protein Atlas | TYRO3PROTEIN |
| Extracellular Domain | Contains two N-terminal immunoglobulin-like domains and two fibronectin type III repeats, responsible for ligand binding (Gas6, Protein S) |
| Transmembrane Domain | Single-pass membrane-spanning helix |
| Intracellular Domain | Contains the tyrosine kinase domain with activation loop and substrate binding sites |
| PI3K/AKT pathway | Major pro-survival signaling cascade |
| MAPK/ERK pathway | Regulates neuronal differentiation and plasticity |
| Associated Diseases | Aging, Diabetes, Ferroptosis, neuroinflammation |
| SciDEX Hypotheses | TYRO3-STAT1 Axis to Preserve Parvalbumin Interneur |
| KG Connections | 18 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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