| Gene Symbol | TFR2PROTEIN |
| Function | is a transmembrane protein that mediates cellular iron uptake and plays a critical role in systemic iron homeostasis. |
| Primary Expression | hepatocytes and is essential for hepcidin regulation[@wallace2007]: - Forms a complex with HFE (hereditary hemochromatosis protein) - HFE-TFR2 complex |
| Amino Acids | 801 aa |
| GeneCards | TFR2PROTEIN |
| Human Protein Atlas | TFR2PROTEIN |
| Large extracellular domain | Contains the transferrin-binding site |
| Single transmembrane domain | Anchors the protein to the membrane |
| Short cytoplasmic tail | Contains internalization signals |
| TFR1 | Kd ~1 nM (high affinity) |
| TFR2 | Kd ~30 nM (lower affinity) |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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