| Gene Symbol | TANKYRASEPROTEIN |
| Aliases | TANKYRASEPROTEIN |
| Chromosome | 8p23.1 |
| N-terminal ANCHOR domains (ANK) | Mediate protein-protein interactions |
| SAM (Sterile Alpha Motif) domain | Self-oligomerization |
| PARP catalytic domain | ADP-ribosyltransferase activity |
| H/EB (Helicase-binding) domain | Regulatory functions |
| APP Processing | Regulates amyloid precursor protein trafficking and processing |
| [Tau](/proteins/tau) Pathology | Affects tau stability and aggregation |
| Synaptic Dysfunction | Impairs synaptic plasticity via Wnt pathway |
| Neuronal Death | PAR accumulation promotes neurotoxicity [@zhang2020] |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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