| Gene Symbol | SYPTEST |
| Full Name | Synaptophysin Test |
| Chromosome | Xp11.23 |
| Protein Type | Protein |
| Function | is a major synaptic vesicle protein and widely used neuronal marker in neurobiology and neurodegenerative disease research. |
| Subcellular Localization | to synaptic vesicles, synaptophysin is extensively used as a immunohistochemical |
| UniProt ID | Search UniProt |
| GeneCards | SYPTEST |
| Human Protein Atlas | SYPTEST |
| Synaptic loss in AD | Masliah et al. demonstrated significant reduction in synaptophysin immunoreactivity in AD hippocampus, correlating with memory deficits [3]. |
| Biomarker potential | CSF synaptophysin levels are being investigated as a biomarker for synaptic degeneration in AD [4]. |
| Relationship to amyloid | Synaptic dysfunction induced by amyloid-beta oligomers includes alterations in synaptophysin expression and distribution [5]. |
| Lewy body dementia | Synaptophysin loss in cortical regions correlates with cognitive symptoms |
| Frontotemporal dementia | Reduced synaptophysin in frontal and temporal cortices |
| Huntington's disease | Early synaptic alterations include synaptophysin changes |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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