| Gene Symbol | SQSTM1P62 |
| Aliases | SQSTM1P62PROTEIN |
| Chromosome | 5q35.3 |
| Function | Sequestosome-1 (p62), also known as SQSTM1, is a multifunctional scaffold protein that plays critical roles in selective autophagy, oxidative stress signaling, and neurodegeneration. |
| GeneCards | SQSTM1P62 |
| Human Protein Atlas | SQSTM1P62 |
| ZZ-type zinc finger domain | Involved in receptor interacting protein (RIP) signaling and NF-κB activation [@geetha2008] |
| LIR (LC3-interacting region) | Critical for binding to LC3/GABARAP proteins on autophagosomal membranes, enabling selective autophagy of ubiquitinated cargo [@noda2010] |
| TBK1 phosphorylation site | Serine 403 in the UBA domain can be phosphorylated by TBK1, enhancing ubiquitin binding affinity [@pilli2012] |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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