protein 3,294 words KG: SNX3PROTEIN
Contents

SNX3 Protein — Sorting Nexin 3 in Neurodegeneration

🔬 Protein Info
Gene SymbolSNX3
Full NameSorting Nexin 3
Chromosome6q21
FunctionSNX3 is a peripheral membrane protein that localizes to early endosomes and functions in several key capacities:
UniProt IDO60443
NCBI Gene ID8724
Ensembl IDENSG00000128967
OMIM604767
GeneCardsSNX3
Human Protein AtlasSNX3
Phosphoinositide bindingPX domain binds PI3P on endosomal membranes
Cargo sequence motifsRecognizes specific sorting motifs in transmembrane cargo
WASH complex recruitmentCoordinates the actin remodeling machinery
VPS26The α-arrestin-like subunit
VPS29The scaffolding subunit
Associated DiseasesParkinson's Disease, Alzheimer's Disease, Neurodegeneration
KG Connections5 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Related Hypotheses (145)

Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Smartphone-Detected Motor Variability Correction
Score: 0.74
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
Aquaporin-4 Polarization Rescue
Score: 0.73
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Adenosine-Astrocyte Metabolic Reset
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
Stress Granule Phase Separation Modulators
Score: 0.72
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Related Analyses (28)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40
Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40
Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40
Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · completed · Score: 0.40

See Also (15)

Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 139 hypotheses
China Neurodegeneration Epidemiology
disease · Pages share 139 hypotheses
Neuroimaging for Parkinsonian Syndromes (NCT03872102)
clinical · Pages share 27 hypotheses
Synaptic Biomarkers in Neurodegeneration
biomarker · Pages share 139 hypotheses
Olfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 139 hypotheses

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