| Gene Symbol | SERCA |
| Aliases | Sarco/Endoplasmic Reticulum Ca²⁺-ATPase |
| Function | SERCA (Sarco/Endoplasmic Reticulum Ca²⁺-ATPase) pumps calcium ions from the cytosol into the endoplasmic reticulum (ER), maintaining the steep calcium gradient essential for calcium signaling |
| Molecular Weight | 110 kDa |
| GeneCards | SERCA |
| Human Protein Atlas | SERCA |
| E1 | High Ca²⁺ affinity, cytosolic-facing binding sites |
| E1~P | Phosphorylated, Ca²⁺ occluded |
| E2~P | Low Ca²⁺ affinity, luminal release |
| E2 | Dephosphorylated, reset[@toyoshima2000] |
| SERCA1 (ATP2A1) | Fast-twitch skeletal muscle, Brody disease |
| SERCA2 (ATP2A2) | Widespread, brain (SERCA2b dominant), Darier disease |
| SERCA3 (ATP2A3) | Limited distribution, secretory cells |
| Phospholamban | Inhibitory, relieved by PKA phosphorylation |
| Sarcolipin | Inhibitory, controls heat production |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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