| Gene Symbol | SERCA |
| Aliases | Sarco/Endoplasmic Reticulum Ca²⁺-ATPase |
| Function | SERCA (Sarco/Endoplasmic Reticulum Ca²⁺-ATPase) pumps calcium ions from the cytosol into the endoplasmic reticulum (ER), maintaining the steep calcium gradient essential for calcium signaling |
| Molecular Weight | 110 kDa |
| GeneCards | SERCA |
| Human Protein Atlas | SERCA |
| A (actuator) domain | Contains phosphorylated aspartate residue |
| N (nucleotide-binding) domain | Binds ATP |
| P (phosphorylation) domain | Receives phosphate from ATP |
| Transmembrane domain | 10 helices forming calcium transport pathway |
| Calcium binding sites | Two high-affinity sites (sites I and II) |
| High ER calcium | 100-800 μM in ER lumen vs. ~100 nM cytosol |
| Calcium signaling capacity | Stores for IP₃R and RyR release |
| Protein folding environment | Chaperones require calcium |
| ER stress prevention | Maintains UPR homeostasis |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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