protein 2,251 words KG: RHBDF2PROTEIN
Contents

RHBDF2 (iRhom2) Protein

🔬 Protein Info
Gene SymbolRHBDF2
AliasesRHBDF2PROTEIN
Chromosome17q25.1
FunctionThe protein's functions have significant implications for neurodegenerative diseases, particularly Alzheimer's disease (AD) and Parkinson's disease (PD), where chronic neuroinflammation plays a cen...
Subcellular Localization</strong> Endoplasmic reticulum, plasma membrane</div> <div class="infobox-r
GeneCardsRHBDF2
Human Protein AtlasRHBDF2
Active site mutationThe catalytic serine is replaced by a non-functional residue
Substrate-binding pocketRetained but used for protein-protein interactions rather than catalysis
Evolutionary conservationThe pseudoprotease function has been co-opted for regulatory roles
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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