| Gene Symbol | PTPRG |
| Aliases | PTPRGPROTEIN |
| Chromosome | 3p21.2 |
| Function | PTPRG (also known as PTPγ) is a member of the protein tyrosine phosphatase family that plays important roles in regulating cell growth, differentiation, and signal transduction. |
| Molecular Weight | 160 kDa |
| GeneCards | PTPRG |
| Human Protein Atlas | PTPRG |
| Receptor Phosphatase | Dephosphorylates tyrosine residues on target proteins in response to extracellular cues |
| Cell Adhesion | Regulates cell-cell interactions through interaction with contactin proteins |
| Neuronal Development | Controls neuronal migration and cortical layering during brain development |
| Synaptic Plasticity | Modulates postsynaptic signaling and dendritic spine morphology [@stoker2020] |
| [Tau](/proteins/tau) Phosphorylation | PTPRG may regulate kinases involved in tau phosphorylation; dysregulation could contribute to tau pathology |
| Synaptic Deficits | Loss of PTPRG function may exacerbate synaptic dysfunction in AD |
| Aβ Signaling | PTPRG may modulate neuronal responses to amyloid-beta exposure [@wang2021] |
| Dopaminergic Signaling | PTPRG regulates tyrosine hydroxylase activity, potentially affecting dopamine synthesis |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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