| Gene Symbol | PTPRF |
| Aliases | PTPRFPROTEIN |
| Chromosome | 1p35 |
| Function | - Presynaptic Function: PTPRF regulates the phosphorylation state of synaptic vesicle proteins including Synapsin and SV2, modulating neurotransmitter release[@cesca2013] |
| Subcellular Localization | </strong></td><td>Cell membrane, focal adhesions</td></tr> |
| Molecular Weight | 217 kDa |
| Amino Acids | 1465 aa |
| GeneCards | PTPRF |
| Human Protein Atlas | PTPRF |
| N-terminal Signal Peptide | Directs protein to the secretory pathway[@heinz2018]. |
| Proline-rich Region | Contains multiple PXXP motifs that may interact with SH3 domain-containing proteins[@sakuno2014]. |
| D2 (Membrane-distal Phosphatase Domain) | A catalytically inactive phosphatase-like domain that may serve regulatory functions, including substrate recruitment and interaction with the cytoskeleton[@barr2009]. |
| C-terminal Tail | Contains PDZ-binding motifs (E(S/T)XV) that facilitate interactions with PDZ domain-containing proteins including GRIP1, SAP97, and Scribble[@kim2010]. |
| Integrin Signaling | PTPRF dephosphorylates focal adhesion kinase (FAK) and Src family kinases, modulating integrin-mediated adhesion and migration[@ardecky2019]. |
| Cadherin-Catenin Complex | PTPRF dephosphorylates β-catenin and p120-catenin, regulating cadherin-mediated cell-cell adhesion and epithelial integrity[@li2011]. |
| Interactions | PTPRD |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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