| Gene Symbol | PHENYLETHANOLAMINENMETHYLTRANSFERASE |
| Aliases | PHENYLETHANOLAMINENMETHYLTRANSFERASE |
| Chromosome | 5q31.2 |
| S-adenosyl-L-methionine (SAM) | Methyl donor |
| Magnesium ions | Cofactor for substrate binding |
| Norepinephrine | Substrate, converted to epinephrine |
| Stereospecificity | Preferentially methylates the S-enantiomer of norepinephrine |
| Substrate specificity | Also acts on related phenylethanolamines |
| Glucocorticoid regulation | Expression induced by cortisol from adrenal cortex |
| SAH feedback inhibition | Product inhibition regulates enzyme activity |
| Glucocorticoid dependence | Cortisol from adrenal cortex induces PNMT transcription |
| Neural regulation | Splanchnic nerve stimulation increases PNMT activity |
| Developmental expression | Appears late in adrenal development |
| Brain expression | Limited to catecholamine neurons in medulla and hypothalamus |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!