| Gene Symbol | PAK2 |
| Aliases | PAK2PROTEIN |
| Function | The p21-activated kinases (PAKs) represent a family of serine/threonine kinases that function as downstream effectors of small GTPases, particularly RAC1 and CDC42[@bokoch2003]. |
| Subcellular Localization | </strong></td><td>Cytoplasm, Membrane, Nucleus</td></tr> |
| Molecular Weight | 58 kDa |
| Amino Acids | 524 aa |
| GeneCards | PAK2 |
| Human Protein Atlas | PAK2 |
| Microtubule Dynamics | PAK2 interacts with tubulin and regulates microtubule organization in neurons[@kesavapany2007]. This function is particularly important for axonal guidance and dendritic branching. |
| Cell Adhesion | Through effects on focal adhesion kinase (FAK) and paxillin, PAK2 regulates integrin-mediated cell-matrix adhesion and neuronal migration[@zhang2005]. |
| Synaptic Transmission | PAK2 is involved in presynaptic vesicle trafficking and neurotransmitter release[@huber2014]. The protein localizes to synaptic terminals where it regulates the cycling of synaptic vesicles. |
| Long-term Potentiation (LTP) | PAK signaling is required for LTP, the cellular basis of learning and memory. PAK activity is necessary for AMPA receptor trafficking during LTP. |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!
No comments yet. Be the first to comment!