| Gene Symbol | P62SQSTM1 |
| Protein Family | Selective autophagy receptors (SARs) |
| Protein Type | Scaffold Protein |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | nearly all major neurodegenerative diseases, including [alzheimers](/diseases/al |
| Molecular Weight | ~62 kDa |
| Amino Acids | 440 |
| UniProt ID | Q13501 |
| GeneCards | P62SQSTM1 |
| Human Protein Atlas | P62SQSTM1 |
| [nf-kb](/entities/nf-kb) activation | Through TRAF6 and RIP1 recruitment, p62 activates pro-inflammatory nf-kb signaling in response to IL-1, TNF-alpha, and NGF |
| Nrf2 antioxidant response | Accumulated p62 sequesters Keap1, releasing nrf2 to translocate to the nucleus and activate antioxidant gene expression (Komatsu et al., 2010) |
| mTORC1 regulation | p62 recruits mTORC1 to lysosomal membranes via Raptor binding, promoting mtor-neurodegeneration activation and anabolic signaling |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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