| Gene Symbol | NRG4 |
| Aliases | NRG4PROTEIN |
| Function | The neuregulin family comprises multiple isoforms (NRG1-NRG6) that play crucial roles in development, nervous system function, and disease. |
| Subcellular Localization | ** | Plasma membrane, secreted | |
| Molecular Weight | 50 kDa |
| Pathways | PI3K, MAPK |
| GeneCards | NRG4 |
| Human Protein Atlas | NRG4 |
| N-terminal region | Contains a unique domain that distinguishes NRG4 from other neuregulins and influences receptor binding specificity |
| EGF-like domain | The conserved receptor-binding domain necessary for ErbB activation |
| Transmembrane domain | Enables membrane-bound signaling in addition to secreted forms |
| C-terminal tail | Variable region involved in protein-protein interactions |
| Brown adipose tissue (BAT) | NRG4 is highly expressed in brown adipose tissue and regulates thermogenesis |
| Energy expenditure | Promotes uncoupled respiration and heat production in brown adipocytes |
| Insulin sensitivity | Improves glucose metabolism and insulin signaling |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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