| Gene Symbol | NLRP4 |
| Aliases | NLRP4PROTEIN |
| Subcellular Localization | </th><td>Cytoplasm, Nucleus, Endoplasmic reticulum</td></tr> |
| Molecular Weight | 153 kDa |
| GeneCards | NLRP4 |
| Human Protein Atlas | NLRP4 |
| PYD (Pyrin Domain) | N-terminal protein-protein interaction domain |
| NACHT domain | Central ATPase domain involved in oligomerization |
| LRR (Leucine-Rich Repeat) | C-terminal sensor domain for ligand recognition |
| FIIND (Function to Find) | Intermediate domain required for protein maturation |
| Autophagosome formation | Modulates the initiation and expansion of autophagosomes |
| Selective autophagy | Regulates xenophagy and aggrephagy |
| ER-phagy | Participates in endoplasmic reticulum-selective autophagy |
| Chronic neuroinflammation | Impaired NLRP4 leads to uncontrolled NLRP3 activation |
| Microglial activation | Dysregulated inflammasome contributes to microglial pathology [2] |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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